Deformability-induced lift force in curvilinear microchannels for stem cell-derived products purification

E. Guzniczak; M. Jimenez; O. Otto; N. Willoughby; H. Bridle

Deformability-induced lift force in curvilinear microchannels for stem cell-derived products purification

E. Guzniczak^*, M. Jimenez, O. Otto, N. Willoughby, H. Bridle

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper demonstrates how deformability-induced lift force (F_D) contributes to cell focussing and separation in spiral microchannels (traditionally sorting based on size). To study F_D in spiral channels a cellular model of deformability is first proposed; cells of the same size, but of different deformability, are compared in terms of hydrodynamic behaviour at different flowrates to understand the role of F_D in curvilinear microchannels. Results are then used to perform a label-free enrichment of stem cell products from contaminant by-products based on their size and deformability.

Original language	English
Title of host publication	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018
Publisher	Chemical and Biological Microsystems Society
Pages	2049-2052
Number of pages	4
ISBN (Electronic)	9781510897571
Publication status	Published - 2018
Event	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018 - Kaohsiung, Taiwan, Province of China Duration: 11 Nov 2018 → 15 Nov 2018

Conference

Conference	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018
Abbreviated title	MicroTAS 2018
Country/Territory	Taiwan, Province of China
City	Kaohsiung
Period	11/11/18 → 15/11/18

Keywords

Curvilinear microchannel
Deformability
Deformability-induced lift force
Sorting
Stem cells

ASJC Scopus subject areas

General Chemistry
Bioengineering
Chemical Engineering (miscellaneous)
Control and Systems Engineering

Cite this

@inproceedings{8f5ec2ac8f5345b6a77f7b70b50d5eb1,

title = "Deformability-induced lift force in curvilinear microchannels for stem cell-derived products purification",

abstract = "This paper demonstrates how deformability-induced lift force (FD) contributes to cell focussing and separation in spiral microchannels (traditionally sorting based on size). To study FD in spiral channels a cellular model of deformability is first proposed; cells of the same size, but of different deformability, are compared in terms of hydrodynamic behaviour at different flowrates to understand the role of FD in curvilinear microchannels. Results are then used to perform a label-free enrichment of stem cell products from contaminant by-products based on their size and deformability.",

keywords = "Curvilinear microchannel, Deformability, Deformability-induced lift force, Sorting, Stem cells",

author = "E. Guzniczak and M. Jimenez and O. Otto and N. Willoughby and H. Bridle",

note = "Funding Information: We wish to acknowledge the Industrial Biotechnology Innovation Centre (IBioIC) for providing resources for this research. MJ would like to thank the Engineering and Physical Sciences Research Council (EPSRC) for her personal Research Fellowship. OO gratefully acknowledges support by the Federal Ministry of Education and Research of Germany (ZIK grant under agreement no. 03Z22CN11). Publisher Copyright: Copyright {\textcopyright} (2018) by Chemical and Biological Microsystems Society. All rights reserved.; 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018, MicroTAS 2018 ; Conference date: 11-11-2018 Through 15-11-2018",

year = "2018",

language = "English",

pages = "2049--2052",

booktitle = "22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018",

publisher = "Chemical and Biological Microsystems Society",

}

Guzniczak, E, Jimenez, M, Otto, O, Willoughby, N & Bridle, H 2018, Deformability-induced lift force in curvilinear microchannels for stem cell-derived products purification. in 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018. Chemical and Biological Microsystems Society, pp. 2049-2052, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018, Kaohsiung, Taiwan, Province of China, 11/11/18.

Deformability-induced lift force in curvilinear microchannels for stem cell-derived products purification. / Guzniczak, E.; Jimenez, M.; Otto, O. et al.
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018. Chemical and Biological Microsystems Society, 2018. p. 2049-2052.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Deformability-induced lift force in curvilinear microchannels for stem cell-derived products purification

AU - Guzniczak, E.

AU - Jimenez, M.

AU - Otto, O.

AU - Willoughby, N.

AU - Bridle, H.

N1 - Funding Information: We wish to acknowledge the Industrial Biotechnology Innovation Centre (IBioIC) for providing resources for this research. MJ would like to thank the Engineering and Physical Sciences Research Council (EPSRC) for her personal Research Fellowship. OO gratefully acknowledges support by the Federal Ministry of Education and Research of Germany (ZIK grant under agreement no. 03Z22CN11). Publisher Copyright: Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved.

PY - 2018

Y1 - 2018

N2 - This paper demonstrates how deformability-induced lift force (FD) contributes to cell focussing and separation in spiral microchannels (traditionally sorting based on size). To study FD in spiral channels a cellular model of deformability is first proposed; cells of the same size, but of different deformability, are compared in terms of hydrodynamic behaviour at different flowrates to understand the role of FD in curvilinear microchannels. Results are then used to perform a label-free enrichment of stem cell products from contaminant by-products based on their size and deformability.

AB - This paper demonstrates how deformability-induced lift force (FD) contributes to cell focussing and separation in spiral microchannels (traditionally sorting based on size). To study FD in spiral channels a cellular model of deformability is first proposed; cells of the same size, but of different deformability, are compared in terms of hydrodynamic behaviour at different flowrates to understand the role of FD in curvilinear microchannels. Results are then used to perform a label-free enrichment of stem cell products from contaminant by-products based on their size and deformability.

KW - Curvilinear microchannel

KW - Deformability

KW - Deformability-induced lift force

KW - Sorting

KW - Stem cells

UR - http://www.scopus.com/inward/record.url?scp=85079807939&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85079807939

SP - 2049

EP - 2052

BT - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018

PB - Chemical and Biological Microsystems Society

T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences 2018

Y2 - 11 November 2018 through 15 November 2018

ER -

Deformability-induced lift force in curvilinear microchannels for stem cell-derived products purification

Abstract

Conference

Keywords

ASJC Scopus subject areas

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