Current developments on the inhibitory effects of berry polyphenols on digestive enzymes

Gordon J McDougall, Nimish N Kulkarni, Derek Stewart

    Research output: Contribution to journalArticlepeer-review

    107 Citations (Scopus)


    The recent developments and evidence for the effect of polyphenol components of berries on digestive enzymes has been reviewed. Certain plant polyphenols can inhibit starch digestive enzymes in the gastrointestinal tract and modulate blood glucose control in vivo. Certain berry polyphenol components can inhibit protease activities at levels which could affect protein digestion in the gastrointestinal tract. In addition, other polyphenol components show potential for the inhibition of gastrointestinal lipase activity, which is a proven therapeutic target for the control of obesity through reduced fat digestion.

    Taking into account the potential synergies for inhibition of starch and lipid digestion by the spectrum of polyphenol components present within berry species, the inhibition of digestive enzymes by dietary polyphenols may be another important mechanism for the health benefits attributed to a diet rich in fruit and vegetables.
    Copyright © 2008 International Union of Biochemistry and Molecular Biology, Inc
    Original languageEnglish
    Pages (from-to)73-80
    Number of pages8
    Issue number1
    Publication statusPublished - 2008


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