@inbook{0633b3c72ce64141a69748f62dd74e6e,
title = "Current and Emerging 3D Models to Study Breast Cancer",
abstract = "For decades 2D culture has been used to study breast cancer. In recent years, however, the importance of 3D culture to recapitulate the complexity of human disease has received attention. A breakthrough for 3D culture came as a result of a Nature editorial {\textquoteleft}Goodbye Flat Biology{\textquoteright} (Anonymous, Nature 424:861–861, 2003). Since then scientists have developed and implemented a range of different and more clinically relevant models, which are used to study breast cancer. In this chapter multiple different 3D models will be discussed including spheroids, microfluidic and bio-printed models and in silico models.",
keywords = "3D, Bio-printing, Breast cancer, Microfluidics, Primary culture, Spheroids, Virtual pathology, bone metastasis, breast cancer statistics, breast cancer stem cells, tamoxifen, triple negative breast cancer, antibacterial drug resistance",
author = "Sophie Roberts and Sally Peyman and Valerie Speirs",
note = "Publisher Copyright: {\textcopyright} 2019, Springer Nature Switzerland AG.",
year = "2019",
month = aug,
day = "28",
doi = "10.1007/978-3-030-20301-6_22",
language = "English",
isbn = "9783030203009",
volume = "1152",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "413--427",
booktitle = "Advances in Experimental Medicine and Biology",
address = "United States",
}
