Critical comparison of intravenous injection of TiO2 nanoparticles with waterborne and dietary exposures concludes minimal environmentally-relevant toxicity in juvenile rainbow trout Oncorhynchus mykiss

David Boyle, Genan A Al-Bairuty, Theodore B Henry, Richard D Handy

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Abstract

    A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of results after intravenous caudal-vein injection of 50 mu g of TiO2-NPs and bulk TiO2. Injected TiO2-NPs accumulated only in kidney (94% of measured Ti) and to a lesser extent in spleen; and injected bulk TiO2 was found only in kidney. No toxicity of TiO2 was observed in kidney, spleen, or other tissues. Critical comparison of these data with previous studies indicates that dietary and waterborne exposures to TiO2-NPs do not lead to Ti accumulation in internal tissues, and previous reports of minor toxicity are inconsistent or attributable to respiratory distress resulting from gill occlusion during waterborne exposure. (C) 2013 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)70-79
    Number of pages10
    JournalEnvironmental Pollution
    Volume182
    DOIs
    Publication statusPublished - Nov 2013

    Keywords

    • Nanoparticles
    • Titanium dioxide
    • Rainbow trout
    • Toxicity
    • Bioavailability
    • TITANIUM-DIOXIDE NANOPARTICLES
    • OXIDATIVE STRESS
    • FISH CELLS
    • ZEBRAFISH
    • ECOTOXICOLOGY
    • INJURY
    • TISSUE
    • BRAIN

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