Critical comparison of intravenous injection of TiO2 nanoparticles with waterborne and dietary exposures concludes minimal environmentally-relevant toxicity in juvenile rainbow trout Oncorhynchus mykiss

David Boyle, Genan A Al-Bairuty, Theodore B Henry, Richard D Handy

    Research output: Contribution to journalArticle

    Abstract

    A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of results after intravenous caudal-vein injection of 50 mu g of TiO2-NPs and bulk TiO2. Injected TiO2-NPs accumulated only in kidney (94% of measured Ti) and to a lesser extent in spleen; and injected bulk TiO2 was found only in kidney. No toxicity of TiO2 was observed in kidney, spleen, or other tissues. Critical comparison of these data with previous studies indicates that dietary and waterborne exposures to TiO2-NPs do not lead to Ti accumulation in internal tissues, and previous reports of minor toxicity are inconsistent or attributable to respiratory distress resulting from gill occlusion during waterborne exposure. (C) 2013 Elsevier Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)70-79
    Number of pages10
    JournalEnvironmental Pollution
    Volume182
    DOIs
    Publication statusPublished - Nov 2013

    Keywords

    • Nanoparticles
    • Titanium dioxide
    • Rainbow trout
    • Toxicity
    • Bioavailability
    • TITANIUM-DIOXIDE NANOPARTICLES
    • OXIDATIVE STRESS
    • FISH CELLS
    • ZEBRAFISH
    • ECOTOXICOLOGY
    • INJURY
    • TISSUE
    • BRAIN

    Cite this

    @article{2d00a7346dac4f6cbaec9f6afa7033c9,
    title = "Critical comparison of intravenous injection of TiO2 nanoparticles with waterborne and dietary exposures concludes minimal environmentally-relevant toxicity in juvenile rainbow trout Oncorhynchus mykiss",
    abstract = "A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of results after intravenous caudal-vein injection of 50 mu g of TiO2-NPs and bulk TiO2. Injected TiO2-NPs accumulated only in kidney (94{\%} of measured Ti) and to a lesser extent in spleen; and injected bulk TiO2 was found only in kidney. No toxicity of TiO2 was observed in kidney, spleen, or other tissues. Critical comparison of these data with previous studies indicates that dietary and waterborne exposures to TiO2-NPs do not lead to Ti accumulation in internal tissues, and previous reports of minor toxicity are inconsistent or attributable to respiratory distress resulting from gill occlusion during waterborne exposure. (C) 2013 Elsevier Ltd. All rights reserved.",
    keywords = "Nanoparticles, Titanium dioxide, Rainbow trout, Toxicity, Bioavailability, TITANIUM-DIOXIDE NANOPARTICLES, OXIDATIVE STRESS, FISH CELLS, ZEBRAFISH, ECOTOXICOLOGY, INJURY, TISSUE, BRAIN",
    author = "David Boyle and Al-Bairuty, {Genan A} and Henry, {Theodore B} and Handy, {Richard D}",
    year = "2013",
    month = "11",
    doi = "10.1016/j.envpol.2013.07.001",
    language = "English",
    volume = "182",
    pages = "70--79",
    journal = "Environmental Pollution",
    issn = "0269-7491",
    publisher = "Elsevier Limited",

    }

    TY - JOUR

    T1 - Critical comparison of intravenous injection of TiO2 nanoparticles with waterborne and dietary exposures concludes minimal environmentally-relevant toxicity in juvenile rainbow trout Oncorhynchus mykiss

    AU - Boyle, David

    AU - Al-Bairuty, Genan A

    AU - Henry, Theodore B

    AU - Handy, Richard D

    PY - 2013/11

    Y1 - 2013/11

    N2 - A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of results after intravenous caudal-vein injection of 50 mu g of TiO2-NPs and bulk TiO2. Injected TiO2-NPs accumulated only in kidney (94% of measured Ti) and to a lesser extent in spleen; and injected bulk TiO2 was found only in kidney. No toxicity of TiO2 was observed in kidney, spleen, or other tissues. Critical comparison of these data with previous studies indicates that dietary and waterborne exposures to TiO2-NPs do not lead to Ti accumulation in internal tissues, and previous reports of minor toxicity are inconsistent or attributable to respiratory distress resulting from gill occlusion during waterborne exposure. (C) 2013 Elsevier Ltd. All rights reserved.

    AB - A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of results after intravenous caudal-vein injection of 50 mu g of TiO2-NPs and bulk TiO2. Injected TiO2-NPs accumulated only in kidney (94% of measured Ti) and to a lesser extent in spleen; and injected bulk TiO2 was found only in kidney. No toxicity of TiO2 was observed in kidney, spleen, or other tissues. Critical comparison of these data with previous studies indicates that dietary and waterborne exposures to TiO2-NPs do not lead to Ti accumulation in internal tissues, and previous reports of minor toxicity are inconsistent or attributable to respiratory distress resulting from gill occlusion during waterborne exposure. (C) 2013 Elsevier Ltd. All rights reserved.

    KW - Nanoparticles

    KW - Titanium dioxide

    KW - Rainbow trout

    KW - Toxicity

    KW - Bioavailability

    KW - TITANIUM-DIOXIDE NANOPARTICLES

    KW - OXIDATIVE STRESS

    KW - FISH CELLS

    KW - ZEBRAFISH

    KW - ECOTOXICOLOGY

    KW - INJURY

    KW - TISSUE

    KW - BRAIN

    U2 - 10.1016/j.envpol.2013.07.001

    DO - 10.1016/j.envpol.2013.07.001

    M3 - Article

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    SP - 70

    EP - 79

    JO - Environmental Pollution

    JF - Environmental Pollution

    SN - 0269-7491

    ER -