Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

Luis M Fidalgo; Graeme Whyte; Brandon T Ruotolo; Justin L P Benesch; Florian Stengel; Chris Abell; Carol V Robinson; Wilhelm T S Huck

doi:10.1002/anie.200806103

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

Luis M Fidalgo, Graeme Whyte, Brandon T Ruotolo, Justin L P Benesch, Florian Stengel, Chris Abell, Carol V Robinson, Wilhelm T S Huck

Research output: Contribution to journal › Article › peer-review

156 Citations (Scopus)

Abstract

Fully integrated: Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 microm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on-chip protein evolution and chemical synthesis.

Original language	English
Pages (from-to)	3665-3668
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	48
Issue number	20
DOIs	https://doi.org/10.1002/anie.200806103
Publication status	Published - Jan 2009

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10.1002/anie.200806103

http://www.ncbi.nlm.nih.gov/pubmed/19353614

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title = "Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.",

abstract = "Fully integrated: Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 microm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on-chip protein evolution and chemical synthesis.",

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AU - Fidalgo, Luis M

AU - Whyte, Graeme

AU - Ruotolo, Brandon T

AU - Benesch, Justin L P

AU - Stengel, Florian

AU - Abell, Chris

AU - Robinson, Carol V

AU - Huck, Wilhelm T S

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AB - Fully integrated: Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 microm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on-chip protein evolution and chemical synthesis.

U2 - 10.1002/anie.200806103

DO - 10.1002/anie.200806103

M3 - Article

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JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 20

ER -

Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online.

Abstract

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