Fully integrated: Mass spectrometry has been integrated into a detection scheme for microdroplets that are created within microfluidic channels (see picture, scale bar 200 microm). This technique allows droplets to be identified based on the compounds they contain, and combines fluorescence screening with MS analysis. These experiments indicate how similar approaches can be applied to the ambitious goals of on-chip protein evolution and chemical synthesis.
Fidalgo, L. M., Whyte, G., Ruotolo, B. T., Benesch, J. L. P., Stengel, F., Abell, C., Robinson, C. V., & Huck, W. T. S. (2009). Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets online. Angewandte Chemie International Edition, 48(20), 3665-3668. https://doi.org/10.1002/anie.200806103