Conversion of secopenicillanic acid derivatives into β-lactam sulphimides and oxazolines

Malcolm M Campbell, Graham Johnson

Research output: Contribution to journalArticle

Abstract

4-(Methylthio)azetidin-2-ones when treated with chloramine T gave in each case a single sulphimide enantiomer, together with both possible sulphoxides. The sulphimides were readily converted by heating, or by attempted oxidation or reduction, into ß-lactam fused oxazolines. The 4-methylthio-3- (triphenylmethylamino)azetidin-2-one derivative did not undergo comparable reaction with chloramine T.

Original languageEnglish
Pages (from-to)1077-1081
Number of pages5
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number12
Publication statusPublished - 1975

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