Control of division gene expression in Escherichia coli

Susan J. Dewar, Robert Dorazi

    Research output: Contribution to journalLiterature reviewpeer-review

    24 Citations (Scopus)


    Duplication of the Escherichia coli bacterial cell culminates in the formation of a division septum that splits the progenitor cell into two identical daughter cells. Invagination of the cell envelope is brought about by the co-ordinated interplay of a family of septation-specific proteins that act locally at mid-cell at a specific time in the cell cycle. The majority of the genes known to be required for septum formation are found within the large mra cluster located at 2 min on the E. coli genetic map (nucleotides 89 552-107 474). Examination of the controls exerted on the mra operon shows that E. coli uses an extraordinary range of strategies to co-ordinate the expression of the cell division genes with respect to each other and to the cell cycle. Copyright (C) 2000 Federation of European Microbiological Societies.

    Original languageEnglish
    Pages (from-to)1-7
    Number of pages7
    JournalFEMS Microbiology Letters
    Issue number1
    Publication statusPublished - 1 Jun 2000


    • Cell division
    • Escherichia coli
    • Fts protein
    • Gene expression
    • Regulation
    • Transcriptional organization


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