Contribution of fluid in bone extravascular matrix to strain-rate dependent stiffening of bone tissue – a poroelastic study

Solenn Marie Le Pense, Yuhang Chen

Research output: Contribution to journalArticle

Abstract

Osteoporotic fractures represent an increasing cost to society, and its diagnosis methods based on bone density still lack accuracy in identifying risk of fracture. This is why a better understanding of mechanical behavior of bone tissue is of importance, especially when it comes to relating experimental observations to realistic physiological fall loading conditions. This study aims at exploring the stiffening effect of pore fluid in bone extravascular matrix subject to high strain rate loading that is more realistic to simulate a physiological fall. A computational approach is used, where bone tissue microstructure extracted from micro-CT images is modeled using finite elements. The solid phase of bone tissue is modeled as a poroelastic material, a porous matrix filled with fluid. When the extravascular matrix experiences certain volumetric deformation, the fluid in pores presents load carrying capacity, which consequently varies the apparent stiffness of bone tissue. It is shown that effects of fluid stiffening in bone can be significant, depending on the chosen material properties, the amount of volumetric strain in tissue and the loading rate with respect to hydraulic conductivity and drainage conditions. It is also shown that such stiffening effect is influenced by bone microstructure, and is more significant in cortical bone than in trabecular bone.
Original languageEnglish
Pages (from-to)90–101
Number of pages12
JournalJournal of the Mechanical Behavior of Biomedical Materials
Volume65
Early online date13 Aug 2016
DOIs
Publication statusPublished - Jan 2017

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Strain rate
Bone
Tissue
Fluids
Microstructure
Hydraulic conductivity
Load limits
Drainage
Materials properties
Stiffness
Costs

Cite this

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title = "Contribution of fluid in bone extravascular matrix to strain-rate dependent stiffening of bone tissue – a poroelastic study",
abstract = "Osteoporotic fractures represent an increasing cost to society, and its diagnosis methods based on bone density still lack accuracy in identifying risk of fracture. This is why a better understanding of mechanical behavior of bone tissue is of importance, especially when it comes to relating experimental observations to realistic physiological fall loading conditions. This study aims at exploring the stiffening effect of pore fluid in bone extravascular matrix subject to high strain rate loading that is more realistic to simulate a physiological fall. A computational approach is used, where bone tissue microstructure extracted from micro-CT images is modeled using finite elements. The solid phase of bone tissue is modeled as a poroelastic material, a porous matrix filled with fluid. When the extravascular matrix experiences certain volumetric deformation, the fluid in pores presents load carrying capacity, which consequently varies the apparent stiffness of bone tissue. It is shown that effects of fluid stiffening in bone can be significant, depending on the chosen material properties, the amount of volumetric strain in tissue and the loading rate with respect to hydraulic conductivity and drainage conditions. It is also shown that such stiffening effect is influenced by bone microstructure, and is more significant in cortical bone than in trabecular bone.",
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AB - Osteoporotic fractures represent an increasing cost to society, and its diagnosis methods based on bone density still lack accuracy in identifying risk of fracture. This is why a better understanding of mechanical behavior of bone tissue is of importance, especially when it comes to relating experimental observations to realistic physiological fall loading conditions. This study aims at exploring the stiffening effect of pore fluid in bone extravascular matrix subject to high strain rate loading that is more realistic to simulate a physiological fall. A computational approach is used, where bone tissue microstructure extracted from micro-CT images is modeled using finite elements. The solid phase of bone tissue is modeled as a poroelastic material, a porous matrix filled with fluid. When the extravascular matrix experiences certain volumetric deformation, the fluid in pores presents load carrying capacity, which consequently varies the apparent stiffness of bone tissue. It is shown that effects of fluid stiffening in bone can be significant, depending on the chosen material properties, the amount of volumetric strain in tissue and the loading rate with respect to hydraulic conductivity and drainage conditions. It is also shown that such stiffening effect is influenced by bone microstructure, and is more significant in cortical bone than in trabecular bone.

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