TY - JOUR
T1 - Continuous Hydrogenation of Alkynol in a Continuous Oscillatory Baffled Reactor
AU - Navarro-Fuentes, Francisca
AU - Keane, Mark Andrew
AU - Ni, Xiong Wei
N1 - Funding Information:
The authors wish to acknowledge the financial support from EPSRC Manufacturing Research Hub Programme (grant no. EP/K503289/1).
Publisher Copyright:
© 2021 American Chemical Society.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2/19
Y1 - 2021/2/19
N2 - In this paper, we report, for the first time, that a multiphase catalytic hydrogenation of 3-butyn-2-ol over Pd/Al2O3 catalyst has successfully been running in a continuous oscillatory baffled reactor (COBR) for over 12 h. Catalyst stability and attrition were examined, the results show that there was no catalyst loss for the whole duration of operation, the catalyst was stable for 9 h with 97% selectivity at a target conversion of 95%. Catalyst deactivation thereafter was assessed at a rate of 0.03% per h, this means that it would take 17 days (or 2040 cycles) of operation to achieve 50% of the target conversion. This is significantly better than the corresponding batch operation where half catalyst activity was reached after 32 cycles. In addition, one of the advantages of using COBR is that it allows the screening of several operational parameters in a single reaction run, as the steady state of operation was readily attained within 1 to 1.5 residence times.
AB - In this paper, we report, for the first time, that a multiphase catalytic hydrogenation of 3-butyn-2-ol over Pd/Al2O3 catalyst has successfully been running in a continuous oscillatory baffled reactor (COBR) for over 12 h. Catalyst stability and attrition were examined, the results show that there was no catalyst loss for the whole duration of operation, the catalyst was stable for 9 h with 97% selectivity at a target conversion of 95%. Catalyst deactivation thereafter was assessed at a rate of 0.03% per h, this means that it would take 17 days (or 2040 cycles) of operation to achieve 50% of the target conversion. This is significantly better than the corresponding batch operation where half catalyst activity was reached after 32 cycles. In addition, one of the advantages of using COBR is that it allows the screening of several operational parameters in a single reaction run, as the steady state of operation was readily attained within 1 to 1.5 residence times.
KW - catalyst deactivation
KW - continuous hydrogenation
KW - continuous oscillatory baffled reactor
KW - reaction rate
KW - selectivity
UR - http://www.scopus.com/inward/record.url?scp=85099953463&partnerID=8YFLogxK
U2 - 10.1021/acs.oprd.0c00458
DO - 10.1021/acs.oprd.0c00458
M3 - Article
AN - SCOPUS:85099953463
SN - 1083-6160
VL - 25
SP - 206
EP - 211
JO - Organic Process Research and Development
JF - Organic Process Research and Development
IS - 2
ER -