Continuous crystallization of pharmaceuticals using a continuous oscillatory baffled crystallizer

Simon Lawton; Gerry Steele; Phil Shering; Lihua Zhao; Ian Laird; Xiong W. Ni

doi:10.1021/op900237x

Continuous crystallization of pharmaceuticals using a continuous oscillatory baffled crystallizer

Simon Lawton, Gerry Steele, Phil Shering, Lihua Zhao, Ian Laird, Xiong W. Ni

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

323 Citations (Scopus)

Abstract

In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation and costs, and delivers the isolation of the model API in just over 12 min compared to the 9 h and 40 min in a batch process. © 2009 American Chemical Society.

Original language	English
Pages (from-to)	1357-1363
Number of pages	7
Journal	Organic Process Research and Development
Volume	13
Issue number	6
DOIs	https://doi.org/10.1021/op900237x
Publication status	Published - 20 Nov 2009

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AU - Ni, Xiong W.

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AB - In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation and costs, and delivers the isolation of the model API in just over 12 min compared to the 9 h and 40 min in a batch process. © 2009 American Chemical Society.

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Continuous crystallization of pharmaceuticals using a continuous oscillatory baffled crystallizer

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