Continuous crystallization of pharmaceuticals using a continuous oscillatory baffled crystallizer

Simon Lawton, Gerry Steele, Phil Shering, Lihua Zhao, Ian Laird, Xiong W. Ni

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation and costs, and delivers the isolation of the model API in just over 12 min compared to the 9 h and 40 min in a batch process. © 2009 American Chemical Society.

Original languageEnglish
Pages (from-to)1357-1363
Number of pages7
JournalOrganic Process Research and Development
Volume13
Issue number6
DOIs
Publication statusPublished - 20 Nov 2009

Fingerprint Dive into the research topics of 'Continuous crystallization of pharmaceuticals using a continuous oscillatory baffled crystallizer'. Together they form a unique fingerprint.

  • Cite this