Confirmation of the site of nitrosation in tryptophan derivatives by α-chymotrypsin

T B Brown, M. F G Stevens

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


N-Aroyl derivatives of aromatic hydrophobic L-amino-acid esters (1)-(7) are hydrolysed by a-chymotrypsin to the corresponding L-amino-acids (8)-(14). When the amidic nitrogen atom is incorporated into a heterocyclic ring, e.g. in the benzotriazinones (15a and b), substrate properties are lost. The N-nitroso-derivatives of N-acetyl-L-tryptophan methyl and ethyl esters are smoothly hydrolysed by a-chymotrypsin; their nitroso-groups are therefore attached to the indolic rather than the amidic nitrogen atom.

Original languageEnglish
Pages (from-to)2357-2360
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number22
Publication statusPublished - 1975


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