Computer-aided Design and Fabrication of Bio-Mimetic Materials and Scaffold Micro-structures

Yuhang Chen, Joseph Cadman, Shiwei Zhou, Qing Li

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Computer-aided design (CAD) has proven effective in enabling novel approaches for tissue engineering applications. This paper demonstrates the applicability of various mathematical methods to design and fabricate bio-mimetic materials via two illustrative examples. Firstly, CAD models of cellular biomaterials that mimic the micro-structure of cuttlefish bone are designed based on the principles of the homogenization method. Secondly, a three-dimensional bi-objective topology optimization approach based upon the inverse homogenization method is used to design scaffold micro-structures with tailored effective stiffness and permeability properties. Consequently, solid free-form fabrication is used to fabricate such cellular bio-mimetic materials, which show a great potential in tissue engineering applications.

Original languageEnglish
Pages (from-to)628-632
Number of pages5
JournalAdvanced Materials Research
Publication statusPublished - 2011
EventInternational Conference on Advanced Material Research - Chongqing
Duration: 21 Jan 201123 Jan 2011


  • Bio-mimetic materials
  • Computer-aided design (CAD)
  • Solid free-form fabrication (SFF)
  • Homogenization method
  • Scaffold
  • Tissue Engineering


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