Abstract
Computer-aided design (CAD) has proven effective in enabling novel approaches for tissue engineering applications. This paper demonstrates the applicability of various mathematical methods to design and fabricate bio-mimetic materials via two illustrative examples. Firstly, CAD models of cellular biomaterials that mimic the micro-structure of cuttlefish bone are designed based on the principles of the homogenization method. Secondly, a three-dimensional bi-objective topology optimization approach based upon the inverse homogenization method is used to design scaffold micro-structures with tailored effective stiffness and permeability properties. Consequently, solid free-form fabrication is used to fabricate such cellular bio-mimetic materials, which show a great potential in tissue engineering applications.
Original language | English |
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Pages (from-to) | 628-632 |
Number of pages | 5 |
Journal | Advanced Materials Research |
Volume | 213 |
DOIs | |
Publication status | Published - 2011 |
Event | International Conference on Advanced Material Research - Chongqing Duration: 21 Jan 2011 → 23 Jan 2011 |
Keywords
- Bio-mimetic materials
- Computer-aided design (CAD)
- Solid free-form fabrication (SFF)
- Homogenization method
- Scaffold
- Tissue Engineering