Comparison of the effects of a benzotriazinium iodide and quinidine on guinea-pig heart

A M French, N C Scott

Research output: Contribution to journalArticle

Abstract

The actions of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI) and quinidine were compared on guinea-pig heart preparations. Quinidine had negative inotropic and chronotropic effects on guinea-pig isolated atria and on Langendorff hearts: TnPBI had negative inotropic and chronotropic effects on Langendorff hearts, but showed a positive inotropic effect on isolated atria at low dose levels. Both quinidine and TnPBI increased the effective refractory period of guinea-pig atrial preparations. The effects of TnPBI on transmembrane action potentials indicated a mixed class I and class III action according to the classification of Vaughan Williams (1970). These effects are discussed in relation to the antiarrhythmic actions of TnPBI.

Original languageEnglish
Pages (from-to)19-24
Number of pages6
JournalBritish Journal of Pharmacology
Volume66
Issue number1
Publication statusPublished - 1979

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Quinidine
Iodides
Guinea Pigs
Membrane Potentials
Action Potentials
2-n-propyl-4-4-tolylamino-1,2,3-benzotriazinium

Cite this

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abstract = "The actions of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI) and quinidine were compared on guinea-pig heart preparations. Quinidine had negative inotropic and chronotropic effects on guinea-pig isolated atria and on Langendorff hearts: TnPBI had negative inotropic and chronotropic effects on Langendorff hearts, but showed a positive inotropic effect on isolated atria at low dose levels. Both quinidine and TnPBI increased the effective refractory period of guinea-pig atrial preparations. The effects of TnPBI on transmembrane action potentials indicated a mixed class I and class III action according to the classification of Vaughan Williams (1970). These effects are discussed in relation to the antiarrhythmic actions of TnPBI.",
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Comparison of the effects of a benzotriazinium iodide and quinidine on guinea-pig heart. / French, A M; Scott, N C.

In: British Journal of Pharmacology, Vol. 66, No. 1, 1979, p. 19-24.

Research output: Contribution to journalArticle

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AB - The actions of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI) and quinidine were compared on guinea-pig heart preparations. Quinidine had negative inotropic and chronotropic effects on guinea-pig isolated atria and on Langendorff hearts: TnPBI had negative inotropic and chronotropic effects on Langendorff hearts, but showed a positive inotropic effect on isolated atria at low dose levels. Both quinidine and TnPBI increased the effective refractory period of guinea-pig atrial preparations. The effects of TnPBI on transmembrane action potentials indicated a mixed class I and class III action according to the classification of Vaughan Williams (1970). These effects are discussed in relation to the antiarrhythmic actions of TnPBI.

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