Combinatorial discovery of polymers resistant to bacterial attachment

Andrew L. Hook, Chien-Yi Chang, Jing Yang, Jeni Luckett, Alan Cockayne, Steve Atkinson, Ying Mei, Roger Bayston, Derek J. Irvine, Robert Langer, Daniel G. Anderson, Paul Williams, Martyn C. Davies, Morgan R. Alexander

    Research output: Contribution to journalArticle

    186 Citations (Scopus)

    Abstract

    Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput microarray format. Using this method, we identified a group of structurally related materials comprising ester and cyclic hydrocarbon moieties that substantially reduced the attachment of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli). Coating silicone with these 'hit' materials achieved up to a 30-fold (96.7%) reduction in the surface area covered by bacteria compared with a commercial silver hydrogel coating in vitro, and the same material coatings were effective at reducing bacterial attachment in vivo in a mouse implant infection model. These polymers represent a class of materials that reduce the attachment of bacteria that could not have been predicted to have this property from the current understanding of bacteria-surface interactions.

    Original languageEnglish
    Pages (from-to)868-875
    Number of pages8
    JournalNature Biotechnology
    Volume30
    Issue number9
    DOIs
    Publication statusPublished - Sep 2012

    ASJC Scopus subject areas

    • Applied Microbiology and Biotechnology
    • Biotechnology
    • Molecular Medicine
    • Bioengineering
    • Biomedical Engineering

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