Cocrystal dissociation and molecular demixing in the solid state

Mark D Eddleston, Gareth O Lloyd, William Jones

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A new cocrystal containing caffeine and theophylline was found to dissociate on heating, with caffeine and theophylline molecules spontaneously demixing and recrystallizing as separate phases, in a solid-solid transition likely driven by an increase in entropy. The morphology and composition of the resulting crystals was determined by transmission electron microscopy.

Original languageEnglish
Pages (from-to)8075-8077
Number of pages3
JournalChemical Communications
Volume48
Issue number65
DOIs
Publication statusPublished - 2012

Keywords

  • PHARMACEUTICAL PHASES
  • CRYSTALLINE SOLIDS
  • CAFFEINE
  • THEOPHYLLINE
  • DIFFRACTION
  • ACIDS
  • DRUG

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