Cocrystal dissociation and molecular demixing in the solid state

Mark D Eddleston; Gareth O Lloyd; William Jones

doi:10.1039/c2cc33412g

Cocrystal dissociation and molecular demixing in the solid state

Mark D Eddleston, Gareth O Lloyd, William Jones

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A new cocrystal containing caffeine and theophylline was found to dissociate on heating, with caffeine and theophylline molecules spontaneously demixing and recrystallizing as separate phases, in a solid-solid transition likely driven by an increase in entropy. The morphology and composition of the resulting crystals was determined by transmission electron microscopy.

Original language	English
Pages (from-to)	8075-8077
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	65
DOIs	https://doi.org/10.1039/c2cc33412g
Publication status	Published - 2012

Keywords

PHARMACEUTICAL PHASES
CRYSTALLINE SOLIDS
CAFFEINE
THEOPHYLLINE
DIFFRACTION
ACIDS
DRUG

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10.1039/c2cc33412g

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title = "Cocrystal dissociation and molecular demixing in the solid state",

abstract = "A new cocrystal containing caffeine and theophylline was found to dissociate on heating, with caffeine and theophylline molecules spontaneously demixing and recrystallizing as separate phases, in a solid-solid transition likely driven by an increase in entropy. The morphology and composition of the resulting crystals was determined by transmission electron microscopy.",

keywords = "PHARMACEUTICAL PHASES, CRYSTALLINE SOLIDS, CAFFEINE, THEOPHYLLINE, DIFFRACTION, ACIDS, DRUG",

author = "Eddleston, {Mark D} and Lloyd, {Gareth O} and William Jones",

year = "2012",

doi = "10.1039/c2cc33412g",

language = "English",

volume = "48",

pages = "8075--8077",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Cocrystal dissociation and molecular demixing in the solid state

AU - Eddleston, Mark D

AU - Lloyd, Gareth O

AU - Jones, William

PY - 2012

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AB - A new cocrystal containing caffeine and theophylline was found to dissociate on heating, with caffeine and theophylline molecules spontaneously demixing and recrystallizing as separate phases, in a solid-solid transition likely driven by an increase in entropy. The morphology and composition of the resulting crystals was determined by transmission electron microscopy.

KW - PHARMACEUTICAL PHASES

KW - CRYSTALLINE SOLIDS

KW - CAFFEINE

KW - THEOPHYLLINE

KW - DIFFRACTION

KW - ACIDS

KW - DRUG

U2 - 10.1039/c2cc33412g

DO - 10.1039/c2cc33412g

M3 - Article

C2 - 22781501

SN - 1359-7345

VL - 48

SP - 8075

EP - 8077

JO - Chemical Communications

JF - Chemical Communications

IS - 65

ER -

Cocrystal dissociation and molecular demixing in the solid state

Abstract

Keywords

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