Clinical and Laboratory Diagnosis

Ruqaiyyah Siddiqui, Ibne Karim M. Ali, Jennifer R. Cope, Naveed Ahmed Khan

Research output: Book/ReportBook


As the clinical course of primary amoebic meningoencephalitis is rapid, prompt detection of amoebae is crucial to increase the likelihood of patient survival by initiating early treatment. In general, due to non-specific and overlapping signs and symptoms of primary amoebic meningoencephalitis with those of bacterial or viral meningitis, and the rarity of N. fowleri infections, most primary amoebic meningoencephalitis cases are diagnosed retrospectively, i.e., during the autopsy examination of brain tissues. However, in live patients, primary amoebic meningoencephalitis is commonly diagnosed through microscopic examination of cerebrospinal fluid specimens. It is time critical to diagnose primary amoebic meningoencephalitis and begin empiric antimicrobial therapy. The diagnosis of primary amoebic meningoencephalitis depends on clinical features together with microscopic and/or molecular identification of the parasites in the cerebrospinal fluid specimens. This overview presents the diagnostic approach to primary amoebic meningoencephalitis.
Original languageEnglish
Place of PublicationNorfolk, UK
PublisherCaister Academic Press
Number of pages17
ISBN (Electronic)9781910190548
ISBN (Print)9781910190531
Publication statusPublished - Jun 2016

Publication series

NameBrain-eating Amoebae: Biology and Pathogenesis of Naegleria fowleri
PublisherCaister Academic Press


  • Amoebida
  • Amœbida
  • Central Nervous System Diseases
  • Central Nervous System Protozoal Infections
  • Central nervous system Diseases
  • Naegleria
  • Naegleria fowleri
  • SCIENCE Life Sciences Biology
  • SCIENCE Life Sciences Microbiology
  • Système nerveux central Maladies


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