TY - JOUR
T1 - Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities
AU - Aribisala, Benjamin S.
AU - Wiseman, Stewart
AU - Morris, Zoe
AU - Valdes-Hernandez, Maria C.
AU - Royle, Natalie A.
AU - Maniega, Susana M.
AU - Gow, Alan J.
AU - Corley, Janie
AU - Bastin, Mark E.
AU - Starr, John
AU - Deary, Ian J.
AU - Wardlaw, Joanna M.
N1 - http://stroke.ahajournals.org/site/misc/ifora.xhtml
Stroke will archive paper in PubMed for NIH / HH / wellcome authors but not RCUK. No gold option but above would be green. Authors can't self-archive.
PY - 2014/2
Y1 - 2014/2
N2 - Background and Purpose White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).Methods We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and visually using the Fazekas scale. We derived latent variables for PVS, WMH, and Inflammation from measured PVS, WMH, and inflammation markers and modelled associations using structural equation modelling.Results After accounting for age, sex, stroke, and vascular risk factors, PVS were significantly associated with WMH (=0.47; PConclusions Circulating inflammatory markers are weakly associated with MR-visible PVS, but not directly with WMH. Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease.
AB - Background and Purpose White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).Methods We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and visually using the Fazekas scale. We derived latent variables for PVS, WMH, and Inflammation from measured PVS, WMH, and inflammation markers and modelled associations using structural equation modelling.Results After accounting for age, sex, stroke, and vascular risk factors, PVS were significantly associated with WMH (=0.47; PConclusions Circulating inflammatory markers are weakly associated with MR-visible PVS, but not directly with WMH. Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease.
KW - aging
KW - inflammation
KW - leukoaraiosis
KW - leukoencephalopathies
KW - magnetic resonance imaging
KW - SMALL-VESSEL DISEASE
KW - C-REACTIVE PROTEIN
KW - MRI
KW - STROKE
KW - BRAIN
UR - https://www.scopus.com/pages/publications/84893675532
U2 - 10.1161/STROKEAHA.113.004059
DO - 10.1161/STROKEAHA.113.004059
M3 - Article
C2 - 24399375
SN - 0039-2499
VL - 45
SP - 605
EP - 607
JO - Stroke: A Journal of Cerebral Circulation
JF - Stroke: A Journal of Cerebral Circulation
IS - 2
ER -