Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities

Benjamin S. Aribisala; Stewart Wiseman; Zoe Morris; Maria C. Valdes-Hernandez; Natalie A. Royle; Susana M. Maniega; Alan J. Gow; Janie Corley; Mark E. Bastin; John Starr; Ian J. Deary; Joanna M. Wardlaw

doi:10.1161/STROKEAHA.113.004059

Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities

Benjamin S. Aribisala, Stewart Wiseman, Zoe Morris, Maria C. Valdes-Hernandez, Natalie A. Royle, Susana M. Maniega, Alan J. Gow, Janie Corley, Mark E. Bastin, John Starr, Ian J. Deary, Joanna M. Wardlaw^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

Background and Purpose White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).

Methods We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and visually using the Fazekas scale. We derived latent variables for PVS, WMH, and Inflammation from measured PVS, WMH, and inflammation markers and modelled associations using structural equation modelling.

Results After accounting for age, sex, stroke, and vascular risk factors, PVS were significantly associated with WMH (=0.47; P

Conclusions Circulating inflammatory markers are weakly associated with MR-visible PVS, but not directly with WMH. Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease.

Original language	English
Pages (from-to)	605-607
Number of pages	3
Journal	Stroke: A Journal of Cerebral Circulation
Volume	45
Issue number	2
DOIs	https://doi.org/10.1161/STROKEAHA.113.004059
Publication status	Published - Feb 2014

Keywords

aging
inflammation
leukoaraiosis
leukoencephalopathies
magnetic resonance imaging
SMALL-VESSEL DISEASE
C-REACTIVE PROTEIN
MRI
STROKE
BRAIN

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Aribisala, B. S., Wiseman, S., Morris, Z., Valdes-Hernandez, M. C., Royle, N. A., Maniega, S. M., Gow, A. J., Corley, J., Bastin, M. E., Starr, J., Deary, I. J., & Wardlaw, J. M. (2014). Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities. Stroke: A Journal of Cerebral Circulation, 45(2), 605-607. https://doi.org/10.1161/STROKEAHA.113.004059

@article{1b9af535640a40fea8cf8592e3109b79,

title = "Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities",

abstract = "Background and Purpose White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).Methods We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and visually using the Fazekas scale. We derived latent variables for PVS, WMH, and Inflammation from measured PVS, WMH, and inflammation markers and modelled associations using structural equation modelling.Results After accounting for age, sex, stroke, and vascular risk factors, PVS were significantly associated with WMH (=0.47; PConclusions Circulating inflammatory markers are weakly associated with MR-visible PVS, but not directly with WMH. Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease.",

keywords = "aging, inflammation, leukoaraiosis, leukoencephalopathies, magnetic resonance imaging, SMALL-VESSEL DISEASE, C-REACTIVE PROTEIN, MRI, STROKE, BRAIN",

author = "Aribisala, {Benjamin S.} and Stewart Wiseman and Zoe Morris and Valdes-Hernandez, {Maria C.} and Royle, {Natalie A.} and Maniega, {Susana M.} and Gow, {Alan J.} and Janie Corley and Bastin, {Mark E.} and John Starr and Deary, {Ian J.} and Wardlaw, {Joanna M.}",

note = "http://stroke.ahajournals.org/site/misc/ifora.xhtml Stroke will archive paper in PubMed for NIH / HH / wellcome authors but not RCUK. No gold option but above would be green. Authors can't self-archive.",

year = "2014",

month = feb,

doi = "10.1161/STROKEAHA.113.004059",

language = "English",

volume = "45",

pages = "605--607",

journal = "Stroke: A Journal of Cerebral Circulation",

issn = "0039-2499",

publisher = "Lippincott, Williams and Wilkins",

number = "2",

}

Aribisala, BS, Wiseman, S, Morris, Z, Valdes-Hernandez, MC, Royle, NA, Maniega, SM, Gow, AJ, Corley, J, Bastin, ME, Starr, J, Deary, IJ & Wardlaw, JM 2014, 'Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities', Stroke: A Journal of Cerebral Circulation, vol. 45, no. 2, pp. 605-607. https://doi.org/10.1161/STROKEAHA.113.004059

Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities. / Aribisala, Benjamin S.; Wiseman, Stewart; Morris, Zoe et al.
In: Stroke: A Journal of Cerebral Circulation, Vol. 45, No. 2, 02.2014, p. 605-607.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities

AU - Aribisala, Benjamin S.

AU - Wiseman, Stewart

AU - Morris, Zoe

AU - Valdes-Hernandez, Maria C.

AU - Royle, Natalie A.

AU - Maniega, Susana M.

AU - Gow, Alan J.

AU - Corley, Janie

AU - Bastin, Mark E.

AU - Starr, John

AU - Deary, Ian J.

AU - Wardlaw, Joanna M.

N1 - http://stroke.ahajournals.org/site/misc/ifora.xhtml Stroke will archive paper in PubMed for NIH / HH / wellcome authors but not RCUK. No gold option but above would be green. Authors can't self-archive.

PY - 2014/2

Y1 - 2014/2

N2 - Background and Purpose White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).Methods We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and visually using the Fazekas scale. We derived latent variables for PVS, WMH, and Inflammation from measured PVS, WMH, and inflammation markers and modelled associations using structural equation modelling.Results After accounting for age, sex, stroke, and vascular risk factors, PVS were significantly associated with WMH (=0.47; PConclusions Circulating inflammatory markers are weakly associated with MR-visible PVS, but not directly with WMH. Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease.

AB - Background and Purpose White matter hyperintensities (WMH) and perivascular spaces (PVS) are features of small vessel disease, found jointly on MRI of older people. Inflammation is a prominent pathological feature of small vessel disease. We examined the association between inflammation, PVS, and WMH in the Lothian Birth Cohort 1936 (N=634).Methods We measured plasma fibrinogen, C-reactive protein, and interleukin-6 and rated PVS in 3 brain regions. We measured WMH volumetrically and visually using the Fazekas scale. We derived latent variables for PVS, WMH, and Inflammation from measured PVS, WMH, and inflammation markers and modelled associations using structural equation modelling.Results After accounting for age, sex, stroke, and vascular risk factors, PVS were significantly associated with WMH (=0.47; PConclusions Circulating inflammatory markers are weakly associated with MR-visible PVS, but not directly with WMH. Longitudinal studies should examine whether visible PVS predate WMH progression and whether inflammation modulators can prevent small vessel disease.

KW - aging

KW - inflammation

KW - leukoaraiosis

KW - leukoencephalopathies

KW - magnetic resonance imaging

KW - SMALL-VESSEL DISEASE

KW - C-REACTIVE PROTEIN

KW - MRI

KW - STROKE

KW - BRAIN

U2 - 10.1161/STROKEAHA.113.004059

DO - 10.1161/STROKEAHA.113.004059

M3 - Article

C2 - 24399375

SN - 0039-2499

VL - 45

SP - 605

EP - 607

JO - Stroke: A Journal of Cerebral Circulation

JF - Stroke: A Journal of Cerebral Circulation

IS - 2

ER -

Circulating inflammatory markers are associated with magnetic resonance imaging-visible perivascular spaces but not directly with white matter hyperintensities

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Keywords

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