Chronological and replicative lifespan of polyploid Saccharomyces cerevisiae (syn. S. pastorianus)

Dawn L Maskell, Alan I Kennedy, Jeff A Hodgson, Katherine A Smart

    Research output: Contribution to journalArticle

    Abstract

    Chronological lifespan may be defined as the result of accumulation of irreversible damage to intracellular components during extended stationary phase, compromising cellular integrity and leading to death and autolysis. In contrast, replicative lifespan relates to the number of divisions an individual cell has undertaken before entering a non-replicative state termed senescence, leading to cell death and autolysis. Both forms of lifespan have been considered to represent models of ageing in higher eukaryotes, yet the relation between chronologically and replicatively aged populations has not been investigated. In this study both forms of lifespan have been investigated in Saccharomyces cerevisiae (Syn. S. pastorianus) to establish the relationship between chronological and replicative ageing.

    Original languageEnglish
    Pages (from-to)201-209
    Number of pages9
    JournalFEMS Yeast Research
    Volume3
    Issue number2
    DOIs
    Publication statusPublished - Apr 2003

    Keywords

    • Barbiturates
    • Cell Cycle
    • Cell Division
    • Centrifugation, Density Gradient
    • Colony Count, Microbial
    • Microscopy, Confocal
    • Phenothiazines
    • Saccharomyces cerevisiae

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