Chemotherapeutic and Disinfection Strategies

While it is fortunate that primary amoebic meningoencephalitis is a rare disease, its rarity makes rigorous studies to find the most effective treatment difficult. The majority of studies rely on in vitro laboratory testing, mouse models of primary amoebic meningoencephalitis, and the few case reports of primary amoebic meningoencephalitis survivors to inform treatment recommendations for primary amoebic meningoencephalitis. In addition, the acquisition of drug resistance is a constant threat due to challenges in developing novel drugs. This chapter will present current treatment recommendations based on recent survivor case reports followed by a discussion of the drugs, treatment interventions used, promising new therapies and disinfection strategies.