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Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)
Ryan T. Cameron
, Ryan G. Coleman
, Jon P. Day
, Krishna C. Yalla
, Miles D. Houslay
, David R. Adams
, Brian K. Shoichet
, George S. Baillie
*
*
Corresponding author for this work
Institute of Chemical Sciences
School of Engineering & Physical Sciences
Research output
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Contribution to journal
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Article
›
peer-review
22
Citations (Scopus)
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Pharmacology, Toxicology and Pharmaceutical Science
Moexipril
100%
Adenosine Phosphate
100%
Phosphodiesterase IV
100%
Phosphodiesterase IV Inhibitor
83%
Anti-Inflammatory Drug
16%
Dipeptidyl Carboxypeptidase Inhibitor
16%
Heat Shock Protein 20
16%
Therapeutic Window
16%
Cyclic Nucleotide Phosphodiesterase
16%
Maximum Tolerated Dose
16%
Cyclic AMP Dependent Protein Kinase
16%
Small Heat Shock Protein
16%
Cyclic Nucleotide
16%
Forskolin
16%
Antiporter
16%
Side Effect
16%
INIS
phosphodiesterases
100%
adenosine monophosphate
100%
nucleotides
27%
proteins
18%
kinases
9%
data
9%
levels
9%
range
9%
inflammation
9%
drugs
9%
enzyme inhibitors
9%
phosphorylation
9%
doses
9%
side effects
9%
heat-shock proteins
9%
angiotensin
9%