Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect

Christopher S Stevenson, Kevin Coote, Ruth Webster, Helinor Johnston, Hazel C Atherton, Andrew Nicholls, June Giddings, Rosemary Sugar, Alan Jackson, Neil J Press, Zarin Brown, Keith Butler, Henry Danahay

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    Abstract

    Repetitive, acute inflammatory insults elicited by cigarette smoke (CS) contribute to the development of chronic obstructive pulmonary disease (COPD), a disorder associated with lung inflammation and mucus hypersecretion. Presently, there is a poor understanding of the acute inflammatory mechanisms involved in this process. The aims of this study were to develop an acute model to investigate temporal inflammatory changes occurring after CS exposure. Rats were exposed to whole body CS (once daily) generated from filtered research cigarettes. Initial studies indicated the generation of a neutrophilic/mucus hypersecreting lung phenotype in
    Original languageEnglish
    Pages (from-to)L514-L522
    JournalAmerican Journal of Physiology: Lung Cellular and Molecular Physiology
    Volume288
    Issue number3
    DOIs
    Publication statusPublished - 1 Mar 2005

    Keywords

    • chronic obstructive pulmonary disease
    • neutrophils
    • smoking
    • cytokine-induced neutrophil chemoattractant

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    Stevenson, C. S., Coote, K., Webster, R., Johnston, H., Atherton, H. C., Nicholls, A., Giddings, J., Sugar, R., Jackson, A., Press, N. J., Brown, Z., Butler, K., & Danahay, H. (2005). Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. American Journal of Physiology: Lung Cellular and Molecular Physiology, 288(3), L514-L522. https://doi.org/10.1152/ajplung.00317.2004