Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect

Christopher S Stevenson; Kevin Coote; Ruth Webster; Helinor Johnston; Hazel C Atherton; Andrew Nicholls; June Giddings; Rosemary Sugar; Alan Jackson; Neil J Press; Zarin Brown; Keith Butler; Henry Danahay

doi:10.1152/ajplung.00317.2004

Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect

Christopher S Stevenson, Kevin Coote, Ruth Webster, Helinor Johnston, Hazel C Atherton, Andrew Nicholls, June Giddings, Rosemary Sugar, Alan Jackson, Neil J Press, Zarin Brown, Keith Butler, Henry Danahay

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Repetitive, acute inflammatory insults elicited by cigarette smoke (CS) contribute to the development of chronic obstructive pulmonary disease (COPD), a disorder associated with lung inflammation and mucus hypersecretion. Presently, there is a poor understanding of the acute inflammatory mechanisms involved in this process. The aims of this study were to develop an acute model to investigate temporal inflammatory changes occurring after CS exposure. Rats were exposed to whole body CS (once daily) generated from filtered research cigarettes. Initial studies indicated the generation of a neutrophilic/mucus hypersecreting lung phenotype in

Original language	English
Pages (from-to)	L514-L522
Journal	American Journal of Physiology: Lung Cellular and Molecular Physiology
Volume	288
Issue number	3
DOIs	https://doi.org/10.1152/ajplung.00317.2004
Publication status	Published - 1 Mar 2005

Keywords

chronic obstructive pulmonary disease
neutrophils
smoking
cytokine-induced neutrophil chemoattractant

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10.1152/ajplung.00317.2004

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Stevenson, C. S., Coote, K., Webster, R., Johnston, H., Atherton, H. C., Nicholls, A., Giddings, J., Sugar, R., Jackson, A., Press, N. J., Brown, Z., Butler, K., & Danahay, H. (2005). Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. American Journal of Physiology: Lung Cellular and Molecular Physiology, 288(3), L514-L522. https://doi.org/10.1152/ajplung.00317.2004

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title = "Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect",

abstract = "Repetitive, acute inflammatory insults elicited by cigarette smoke (CS) contribute to the development of chronic obstructive pulmonary disease (COPD), a disorder associated with lung inflammation and mucus hypersecretion. Presently, there is a poor understanding of the acute inflammatory mechanisms involved in this process. The aims of this study were to develop an acute model to investigate temporal inflammatory changes occurring after CS exposure. Rats were exposed to whole body CS (once daily) generated from filtered research cigarettes. Initial studies indicated the generation of a neutrophilic/mucus hypersecreting lung phenotype in ",

keywords = "chronic obstructive pulmonary disease, neutrophils, smoking , cytokine-induced neutrophil chemoattractant ",

author = "Stevenson, {Christopher S} and Kevin Coote and Ruth Webster and Helinor Johnston and Atherton, {Hazel C} and Andrew Nicholls and June Giddings and Rosemary Sugar and Alan Jackson and Press, {Neil J} and Zarin Brown and Keith Butler and Henry Danahay",

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doi = "10.1152/ajplung.00317.2004",

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Stevenson, CS, Coote, K, Webster, R, Johnston, H, Atherton, HC, Nicholls, A, Giddings, J, Sugar, R, Jackson, A, Press, NJ, Brown, Z, Butler, K & Danahay, H 2005, 'Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect', American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 288, no. 3, pp. L514-L522. https://doi.org/10.1152/ajplung.00317.2004

Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect. / Stevenson, Christopher S; Coote, Kevin; Webster, Ruth et al.
In: American Journal of Physiology: Lung Cellular and Molecular Physiology, Vol. 288, No. 3, 01.03.2005, p. L514-L522.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect

AU - Stevenson, Christopher S

AU - Coote, Kevin

AU - Webster, Ruth

AU - Johnston, Helinor

AU - Atherton, Hazel C

AU - Nicholls, Andrew

AU - Giddings, June

AU - Sugar, Rosemary

AU - Jackson, Alan

AU - Press, Neil J

AU - Brown, Zarin

AU - Butler, Keith

AU - Danahay, Henry

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N2 - Repetitive, acute inflammatory insults elicited by cigarette smoke (CS) contribute to the development of chronic obstructive pulmonary disease (COPD), a disorder associated with lung inflammation and mucus hypersecretion. Presently, there is a poor understanding of the acute inflammatory mechanisms involved in this process. The aims of this study were to develop an acute model to investigate temporal inflammatory changes occurring after CS exposure. Rats were exposed to whole body CS (once daily) generated from filtered research cigarettes. Initial studies indicated the generation of a neutrophilic/mucus hypersecreting lung phenotype in

AB - Repetitive, acute inflammatory insults elicited by cigarette smoke (CS) contribute to the development of chronic obstructive pulmonary disease (COPD), a disorder associated with lung inflammation and mucus hypersecretion. Presently, there is a poor understanding of the acute inflammatory mechanisms involved in this process. The aims of this study were to develop an acute model to investigate temporal inflammatory changes occurring after CS exposure. Rats were exposed to whole body CS (once daily) generated from filtered research cigarettes. Initial studies indicated the generation of a neutrophilic/mucus hypersecreting lung phenotype in

KW - chronic obstructive pulmonary disease

KW - neutrophils

KW - smoking

KW - cytokine-induced neutrophil chemoattractant

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M3 - Article

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SN - 1040-0605

VL - 288

SP - L514-L522

JO - American Journal of Physiology: Lung Cellular and Molecular Physiology

JF - American Journal of Physiology: Lung Cellular and Molecular Physiology

IS - 3

ER -

Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect

Abstract

Keywords

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