Characterization of adhesive properties of red blood cells using surface acoustic wave induced flows for rapid diagnostics

Ninnuja Sivanantha; Charles Ma; David J. Collins; M. Sesen; Jason Brenker; Ross L. Coppel; Adrian Neild; Tuncay Alan

doi:10.1063/1.4895472

Characterization of adhesive properties of red blood cells using surface acoustic wave induced flows for rapid diagnostics

Ninnuja Sivanantha, Charles Ma, David J. Collins, M. Sesen, Jason Brenker, Ross L. Coppel, Adrian Neild, Tuncay Alan

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Abstract

This letter presents a method which employs surface acoustic wave induced acoustic streaming to differentially peel treated red blood cells (RBCs) off a substrate based on their adhesive properties and separate populations of pathological cells from normal ones. We demonstrate the principle of operation by comparing the applied power and time required to overcome the adhesion displayed by healthy, glutaraldehyde-treated or malaria-infected human RBCs. Our experiments indicate that the method can be used to differentiate between various cell populations contained in a 9 μl droplet within 30 s, suggesting potential for rapid diagnostics.

Original language	English
Number of pages	5
Journal	Applied Physics Letters
Volume	105
Issue number	10
DOIs	https://doi.org/10.1063/1.4895472
Publication status	Published - 2014

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abstract = "This letter presents a method which employs surface acoustic wave induced acoustic streaming to differentially peel treated red blood cells (RBCs) off a substrate based on their adhesive properties and separate populations of pathological cells from normal ones. We demonstrate the principle of operation by comparing the applied power and time required to overcome the adhesion displayed by healthy, glutaraldehyde-treated or malaria-infected human RBCs. Our experiments indicate that the method can be used to differentiate between various cell populations contained in a 9 μl droplet within 30 s, suggesting potential for rapid diagnostics.",

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AU - Sivanantha, Ninnuja

AU - Ma, Charles

AU - Collins, David J.

AU - Sesen, M.

AU - Brenker, Jason

AU - Coppel, Ross L.

AU - Neild, Adrian

AU - Alan, Tuncay

N1 - Cited By :16 Export Date: 16 June 2017

PY - 2014

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N2 - This letter presents a method which employs surface acoustic wave induced acoustic streaming to differentially peel treated red blood cells (RBCs) off a substrate based on their adhesive properties and separate populations of pathological cells from normal ones. We demonstrate the principle of operation by comparing the applied power and time required to overcome the adhesion displayed by healthy, glutaraldehyde-treated or malaria-infected human RBCs. Our experiments indicate that the method can be used to differentiate between various cell populations contained in a 9 μl droplet within 30 s, suggesting potential for rapid diagnostics.

AB - This letter presents a method which employs surface acoustic wave induced acoustic streaming to differentially peel treated red blood cells (RBCs) off a substrate based on their adhesive properties and separate populations of pathological cells from normal ones. We demonstrate the principle of operation by comparing the applied power and time required to overcome the adhesion displayed by healthy, glutaraldehyde-treated or malaria-infected human RBCs. Our experiments indicate that the method can be used to differentiate between various cell populations contained in a 9 μl droplet within 30 s, suggesting potential for rapid diagnostics.

U2 - 10.1063/1.4895472

DO - 10.1063/1.4895472

M3 - Article

SN - 0003-6951

VL - 105

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 10

ER -

Characterization of adhesive properties of red blood cells using surface acoustic wave induced flows for rapid diagnostics

Abstract

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