Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock

G. R. Barclay, B. B. Scott, I. H. Wright, P. N. Rogers, David George Emslie Smith, Ian R. Poxton

Research output: Contribution to journalArticle

Abstract

Circulating endotoxin levels and IgG antibodies to a range of Gram-negative bacterial lipopolysaccharides (LPS) (endotoxins) of different sizes and structures were measured daily in three cases of septic shock. There was an inverse relationship between endotoxin levels and cross-reactive antibodies to the core glycolipid (CGL) region of lipopolysaccharide. This suggests that antibody to LPS-CGL was initially consumed by a superabundance of endotoxin, and that a resurgence of intrinsic anti-LPS-CGL antibody levels may be associated with a reduction of circulating endotoxin. The implications of these findings for passive antibody therapy of septic shock are discussed.

Original languageEnglish
Pages (from-to)93-106
Number of pages14
JournalCirculatory Shock
Volume29
Issue number2
Publication statusPublished - Oct 1989

Keywords

  • Adult
  • Anti-Bacterial Agents
  • Antibodies, Bacterial
  • Endotoxins
  • Female
  • Humans
  • Immunoglobulin G
  • Lipopolysaccharides
  • Male
  • Pneumococcal Infections
  • Shock, Septic
  • Time Factors

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  • Cite this

    Barclay, G. R., Scott, B. B., Wright, I. H., Rogers, P. N., Smith, D. G. E., & Poxton, I. R. (1989). Changes in anti-endotoxin-IgG antibody and endotoxaemia in three cases of gram-negative septic shock. Circulatory Shock, 29(2), 93-106.