Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study

Joanna M. Wardlaw, Michael Allerhand, Elizabeth Eadie, Avril Thomas, Janey Corley, Alison Pattie, Adele Taylor, Susan D. Shenkin, Simon Cox, Alan Gow, John M. Starr, Ian J. Deary

Research output: Contribution to journalArticle

Abstract

Cognitive decline and carotid artery atheroma are common at older ages. In community-dwelling subjects, we assessed cognition at ages 70, 73 and 76 and carotid Doppler ultrasound at age 73, to determine whether carotid stenosis was related to cognitive decline. We used latent growth curve models to examine associations between four carotid measures (internal carotid artery stenosis, velocity, pulsatility and resistivity indices) and four cognitive ability domains (memory, visuospatial function, crystallised intelligence, processing speed) adjusted for cognitive ability at age 11, current age, gender and vascular risk factors. Amongst 866 participants, carotid stenosis (median 12.96%) was not associated with cognitive abilities at age 70 or cognitive decline from age 70 to 76. Increased ICA pulsatility and resistivity indices were associated with slower processing speed (both P < 0.001) and worse visuospatial function ( P = 0.036, 0.031, respectively) at age 70, and declining crystallised intelligence from ages 70 to 76 ( P = 0.008, 0.006, respectively). The findings suggest that vascular stiffening, rather than carotid luminal narrowing, adversely influences cognitive ageing and provides a potential target for ameliorating age-related cognitive decline.

Original languageEnglish
Pages (from-to)3042-3052
Number of pages11
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number8
Early online date1 Jan 2016
DOIs
StatePublished - Aug 2017

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Carotid Stenosis
Longitudinal Studies
Cohort Studies
Intelligence
Blood Vessels
Common Carotid Artery
Atherosclerotic Plaques
Cognition

Keywords

  • Carotid stenosis
  • white matter hyperintensities
  • cognition
  • ageing
  • vascular risk factors

Cite this

Wardlaw, J. M., Allerhand, M., Eadie, E., Thomas, A., Corley, J., Pattie, A., ... Deary, I. J. (2017). Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study. Journal of Cerebral Blood Flow and Metabolism, 37(8), 3042-3052. DOI: 10.1177/0271678X16683693

Wardlaw, Joanna M.; Allerhand, Michael; Eadie, Elizabeth; Thomas, Avril; Corley, Janey; Pattie, Alison; Taylor, Adele; Shenkin, Susan D.; Cox, Simon; Gow, Alan; Starr, John M.; Deary, Ian J. / Carotid disease at age 73 and cognitive change from age 70 to 76 years : A longitudinal cohort study.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 37, No. 8, 08.2017, p. 3042-3052.

Research output: Contribution to journalArticle

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Wardlaw, JM, Allerhand, M, Eadie, E, Thomas, A, Corley, J, Pattie, A, Taylor, A, Shenkin, SD, Cox, S, Gow, A, Starr, JM & Deary, IJ 2017, 'Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study' Journal of Cerebral Blood Flow and Metabolism, vol 37, no. 8, pp. 3042-3052. DOI: 10.1177/0271678X16683693

Carotid disease at age 73 and cognitive change from age 70 to 76 years : A longitudinal cohort study. / Wardlaw, Joanna M.; Allerhand, Michael; Eadie, Elizabeth; Thomas, Avril; Corley, Janey; Pattie, Alison; Taylor, Adele; Shenkin, Susan D.; Cox, Simon; Gow, Alan; Starr, John M.; Deary, Ian J.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 37, No. 8, 08.2017, p. 3042-3052.

Research output: Contribution to journalArticle

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Wardlaw JM, Allerhand M, Eadie E, Thomas A, Corley J, Pattie A et al. Carotid disease at age 73 and cognitive change from age 70 to 76 years: A longitudinal cohort study. Journal of Cerebral Blood Flow and Metabolism. 2017 Aug;37(8):3042-3052. Available from, DOI: 10.1177/0271678X16683693