Cardiovascular changes under the microgravity environment and the gut microbiome

Ruqaiyyah Siddiqui, Rizwan Qaisar, Khulood Al-Dahash, Ahmad Hashem Altelly, Adel B. Elmoselhi, Naveed Ahmed Khan

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


In view of the critical role the gut microbiome plays in human health, it has become clear that astronauts' gut microbiota composition changes after spending time in space. Astronauts are exposed to several risks in space, including a protracted period of microgravity, radiation, and mechanical unloading of the body. Several deleterious effects of such an environment are reported, including orthostatic intolerance, cardiovascular endothelial dysfunction, cellular and molecular changes, and changes in the composition of the gut microbiome. Herein, the correlation between the gut microbiome and cardiovascular disease in a microgravity environment is evaluated. Additionally, the relationship between orthostatic hypotension, cardiac shrinkage and arrhythmias during spaceflight, and cellular alterations during spaceflight is reviewed. Given its impact on human health in general, modifying the gut microbiota may significantly promote astronaut health and performance. This is merited, given the prospect of augmented human activities in future space missions.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
JournalLife Sciences in Space Research
Early online date9 Sept 2023
Publication statusPublished - Feb 2024


  • Cardiovascular changes
  • Gut microbiome
  • Microgravity
  • Orthostatic hypotension
  • Space travel

ASJC Scopus subject areas

  • Astronomy and Astrophysics
  • Radiation
  • Agricultural and Biological Sciences (miscellaneous)
  • Health, Toxicology and Mutagenesis
  • Ecology


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