Cancer risk among tetrafluoroethylene synthesis and polymerization workers

Dario Consonni*, Kurt Straif, J. Morel Symons, John A. Tomenson, Ludovic G P M Van Amelsvoort, Anne Sleeuwenhoek, John W. Cherrie, Paolo Bonetti, Ilaria Colombo, David G. Farrar, Pier Alberto Bertazzi

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene, increases the incidence of liver and kidney cancers and leukemia in rats and mice. This is the first time the cancer risk in humans has been explored comprehensively in a cohort mortality study (1950-2008) that included all polytetrafluoroethylene production sites in Europe and North America at the time it was initiated. A job-exposure matrix (1950-2002) was developed for TFE and ammonium perfluoro-octanoate, a chemical used in the polymerization process. National reference rates were used to calculate standardized mortality ratios (SMRs) and 95% confidence intervals. Among 4,773 workers ever exposed to TFE, we found a lower rate of death from most causes, as well as increased risks for cancer of the liver (SMR = 1.27; 95% confidence interval: 0.55, 2.51; 8 deaths) and kidney (SMR = 1.44; 95% confidence interval: 0.69, 2.65; 10 deaths) and for leukemia (SMR = 1.48; 95% confidence interval: 0.77, 2.59; 12 deaths). A nonsignificant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and ammonium perfluoro-octanoate exposures were highly correlated, and therefore their separate effects could not be disentangled. This pattern of findings narrows the range of uncertainty on potential TFE carcinogenicity but cannot conclusively confirm or refute the hypothesis that TFE is carcinogenic to humans.

    Original languageEnglish
    Pages (from-to)350-358
    Number of pages9
    JournalAmerican Journal of Epidemiology
    Issue number3
    Publication statusPublished - Aug 2013


    • cohort studies
    • mortality
    • neoplasms
    • occupational health
    • polytetrafluoroethylene
    • tetrafluoroethylene

    ASJC Scopus subject areas

    • Epidemiology


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