TY - JOUR
T1 - Can the Environmental Phagocyte Acanthamoeba Be a Useful Model to Study SARS-CoV-2 Pathogenicity, Infectivity, and Evasion of Cellular Immune Defenses?
AU - Siddiqui, Ruqaiyyah
AU - Khan, Naveed Ahmed
PY - 2020/8/5
Y1 - 2020/8/5
N2 - Acanthamoeba and macrophages exhibit significant parallels in biochemical, physiological, cellular, and functional aspects. Given the ability of Acanthamoeba to contribute to the evolutionary gain of pathogenicity of a variety of microbial pathogens, here we propose the use of Acanthamoeba as a paradigm to study SARS-CoV-2 pathogenicity, infectivity, and evasion of cellular immune defenses.
AB - Acanthamoeba and macrophages exhibit significant parallels in biochemical, physiological, cellular, and functional aspects. Given the ability of Acanthamoeba to contribute to the evolutionary gain of pathogenicity of a variety of microbial pathogens, here we propose the use of Acanthamoeba as a paradigm to study SARS-CoV-2 pathogenicity, infectivity, and evasion of cellular immune defenses.
KW - Severe acute respiratory syndrome coronavirus 2
KW - environmental phagocyte
KW - COVID-19
KW - model organism
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85088861188&partnerID=MN8TOARS
U2 - 10.1021/acschemneuro.0c00401
DO - 10.1021/acschemneuro.0c00401
M3 - Article
SN - 1948-7193
VL - 11
SP - 2149
EP - 2151
JO - ACS Chemical Neuroscience
JF - ACS Chemical Neuroscience
IS - 15
ER -