Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma?

Boris Michael Holzapfel, Mohit Prashant Chhaya, Ferry Petrus Wilhelmus Melchels, Nina Pauline Holzapfel, Peter Michael Prodinger, Ruediger Von Eisenhart-Rothe, Martijn Van Griensven, Jan Thorsten Schantz, Maximilian Rudert, Dietmar Werner Hutmacher

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Abstract

Resection of musculoskeletal sarcoma can result in large bone defects where regeneration is needed in a quantity far beyond the normal potential of self-healing. In many cases, these defects exhibit a limited intrinsic regenerative potential due to an adjuvant therapeutic regimen, seroma, or infection. Therefore, reconstruction of these defects is still one of the most demanding procedures in orthopaedic surgery. The constraints of common treatment strategies have triggered a need for new therapeutic concepts to design and engineer unparalleled structural and functioning bone grafts. To satisfy the need for long-term repair and good clinical outcome, a paradigm shift is needed from methods to replace tissues with inert medical devices to more biological approaches that focus on the repair and reconstruction of tissue structure and function. It is within this context that the field of bone tissue engineering can offer solutions to be implemented into surgical therapy concepts after resection of bone and soft tissue sarcoma. In this paper we will discuss the implementation of tissue engineering concepts into the clinical field of orthopaedic oncology.

Original languageEnglish
Article number153640
Number of pages10
JournalSarcoma
Volume2013
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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    Holzapfel, B. M., Chhaya, M. P., Melchels, F. P. W., Holzapfel, N. P., Prodinger, P. M., Von Eisenhart-Rothe, R., Van Griensven, M., Schantz, J. T., Rudert, M., & Hutmacher, D. W. (2013). Can bone tissue engineering contribute to therapy concepts after resection of musculoskeletal sarcoma? Sarcoma, 2013, [153640]. https://doi.org/10.1155/2013/153640