Abstract
Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood-brain barrier selectivity and achieve the minimum inhibitory concentration at the target site.
Original language | English |
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Pages (from-to) | 485-490 |
Number of pages | 6 |
Journal | Therapeutic Delivery |
Volume | 14 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2023 |
Keywords
- Amphotericin B
- Administration, Intranasal
- Blood-Brain Barrier
- Brain
- Liver