Can Amphotericin B-mediated effects be limited using intranasal versus intravenous route?

Ruqaiyyah Siddiqui, Timothy Yu Yee Ong, Sutherland Maciver, Naveed Ahmed Khan

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
15 Downloads (Pure)

Abstract

Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood-brain barrier selectivity and achieve the minimum inhibitory concentration at the target site.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
JournalTherapeutic Delivery
Volume14
Issue number8
DOIs
Publication statusPublished - Aug 2023

Keywords

  • Amphotericin B
  • Administration, Intranasal
  • Blood-Brain Barrier
  • Brain
  • Liver

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