Abstract
Showdomycin, 2-ß-D-ribofuranosylmaleimide (1), has been prepared in six stages from 2,3,5-tri-O-benzyl-ß-D-ribofuranosylethyne (2) in 23% overall yield (8% from D-ribose). Dimethoxycarbonylation of (2) afforded the substituted maleic ester (4) which was converted, in two stages, into the crystalline anhydride (10). Ammonolysis followed by ring-closure gave the crystalline maleimide (13), which was debenzylated with boron trichloride to give showdomycin.
Original language | English |
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Pages (from-to) | 225-227 |
Number of pages | 3 |
Journal | Journal of the Chemical Society, Perkin Transactions 1 |
Publication status | Published - 1979 |