1,1-Diethoxy-3-(2,3,5-tri-O-benzyl-ß-D-ribofuranosyl)prop-2-yne (12) has been synthesised from 2,3,5-tri-O-benzyl-D-ribofuranose in 52% yield. Acidic hydrolysis followed by reaction with hydrazine affords 3-(2,3,5-tri-O-benzyl- ß-D-ribofuranosyl)pyrazole (1) in 71% yield. Mild methods have been devised for nitration of pyrazole derivatives at C-4, leading to a synthesis of 4-nitro-3(5)-ß-D-ribofuranosylpyrazole (3) from (1) in 56% overall yield.
|Number of pages||5|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - 1980|