Bubbly cavitating flow generation and investigation of its erosional nature for biomedical applications

Ali Koşar, Muhsincan Sesen, Ozlem Oral, Zeynep Itah, Devrim Gozuacik

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This paper presents a study that investigates the destructive energy output resulting from hydrodynamic bubbly cavitation in microchannels and its potential use in biomedical applications. The research performed in this study includes results from bubbly cavitation experiments and findings showing the destructive effects of bubbly cavitating flow on selected solid specimens and live cells. The bubbles generated by hydrodynamic cavitation are highly destructive at the surfaces of the target medium on which they are carefully focused. The resulting destructive energy output could be effectively used for biomedical treatments, such as destroying kidney stones (renal calculi) or killing cancer cells. Motivated by this potential, the cavitation damage to cancerous cells and material removal from chalk pieces (which possess similar material properties as some kidney stones) was investigated. Our results showed that cavitation could induce damage both on chalk pieces and leukemia/lymphoma cells. We discovered that hydrodynamic cavitation exposure had early and delayed effects on cancer cell survival. Hence, the potential of hydrodynamic bubbly cavitation generated at the microscale for biomedical treatments was revealed using the microchannel configuration as a microorifice (with an inner diameter of 147 μm and a length of 1.52 cm), which acts as the source of bubbly cavitating flows.

Original languageEnglish
Pages (from-to)1337-1346
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume58
Issue number5
DOIs
Publication statusPublished - May 2011

Keywords

  • Bubbly cavitating flow
  • cavitation damage
  • cell death
  • hydrodynamic cavitation
  • microchannel

ASJC Scopus subject areas

  • Biomedical Engineering

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