Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies

Mohit P. Chhaya; Ferry P W Melchels; Paul S. Wiggenhauser; Jan T. Schantz; Dietmar W. Hutmacher

doi:10.1016/B978-1-4557-2852-7.00010-X

Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies

Mohit P. Chhaya, Ferry P W Melchels, Paul S. Wiggenhauser, Jan T. Schantz, Dietmar W. Hutmacher

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Citations (Scopus)

Abstract

Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.

Original language	English
Title of host publication	Biofabrication
Subtitle of host publication	Micro- and Nano-fabrication, Printing, Patterning and Assemblies
Editors	G. Forgacs, W. Sun
Publisher	Elsevier
Pages	183-216
Number of pages	34
ISBN (Print)	9781455728527
DOIs	https://doi.org/10.1016/B978-1-4557-2852-7.00010-X
Publication status	Published - Mar 2013

Keywords

3D cell culture
Additive manufacturing
Adipose tissue engineering
Biofabrication
Biomaterials
CAD
CAM
Co-culture
HAPC
Mastectomy
Preadipocytes
Scaffold
Tissue engineering construct
Vascularization

ASJC Scopus subject areas

Engineering(all)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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10.1016/B978-1-4557-2852-7.00010-X

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title = "Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies",

abstract = "Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.",

keywords = "3D cell culture, Additive manufacturing, Adipose tissue engineering, Biofabrication, Biomaterials, CAD, CAM, Co-culture, HAPC, Mastectomy, Preadipocytes, Scaffold, Tissue engineering construct, Vascularization",

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Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies. / Chhaya, Mohit P.; Melchels, Ferry P W; Wiggenhauser, Paul S.; Schantz, Jan T.; Hutmacher, Dietmar W.

Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies. ed. / G. Forgacs; W. Sun. Elsevier, 2013. p. 183-216.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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AU - Melchels, Ferry P W

AU - Wiggenhauser, Paul S.

AU - Schantz, Jan T.

AU - Hutmacher, Dietmar W.

PY - 2013/3

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AB - Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.

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KW - Co-culture

KW - HAPC

KW - Mastectomy

KW - Preadipocytes

KW - Scaffold

KW - Tissue engineering construct

KW - Vascularization

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A2 - Sun, W.

PB - Elsevier

ER -

Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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