Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies

Mohit P. Chhaya, Ferry P W Melchels, Paul S. Wiggenhauser, Jan T. Schantz, Dietmar W. Hutmacher

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.

Original languageEnglish
Title of host publicationBiofabrication
Subtitle of host publicationMicro- and Nano-fabrication, Printing, Patterning and Assemblies
EditorsG. Forgacs, W. Sun
PublisherElsevier
Pages183-216
Number of pages34
ISBN (Print)9781455728527
DOIs
Publication statusPublished - Mar 2013

Fingerprint

Tissue engineering
Tissue
3D printers
Cosmetics
Silicones
Tumors
Engineers

Keywords

  • 3D cell culture
  • Additive manufacturing
  • Adipose tissue engineering
  • Biofabrication
  • Biomaterials
  • CAD
  • CAM
  • Co-culture
  • HAPC
  • Mastectomy
  • Preadipocytes
  • Scaffold
  • Tissue engineering construct
  • Vascularization

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Chhaya, M. P., Melchels, F. P. W., Wiggenhauser, P. S., Schantz, J. T., & Hutmacher, D. W. (2013). Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies. In G. Forgacs, & W. Sun (Eds.), Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies (pp. 183-216). Elsevier. https://doi.org/10.1016/B978-1-4557-2852-7.00010-X
Chhaya, Mohit P. ; Melchels, Ferry P W ; Wiggenhauser, Paul S. ; Schantz, Jan T. ; Hutmacher, Dietmar W. / Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies. Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies. editor / G. Forgacs ; W. Sun. Elsevier, 2013. pp. 183-216
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Chhaya, MP, Melchels, FPW, Wiggenhauser, PS, Schantz, JT & Hutmacher, DW 2013, Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies. in G Forgacs & W Sun (eds), Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies. Elsevier, pp. 183-216. https://doi.org/10.1016/B978-1-4557-2852-7.00010-X

Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies. / Chhaya, Mohit P.; Melchels, Ferry P W; Wiggenhauser, Paul S.; Schantz, Jan T.; Hutmacher, Dietmar W.

Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies. ed. / G. Forgacs; W. Sun. Elsevier, 2013. p. 183-216.

Research output: Chapter in Book/Report/Conference proceedingChapter

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KW - Co-culture

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KW - Mastectomy

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Chhaya MP, Melchels FPW, Wiggenhauser PS, Schantz JT, Hutmacher DW. Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies. In Forgacs G, Sun W, editors, Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies. Elsevier. 2013. p. 183-216 https://doi.org/10.1016/B978-1-4557-2852-7.00010-X