Abstract
Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.
| Original language | English |
|---|---|
| Title of host publication | Biofabrication |
| Subtitle of host publication | Micro- and Nano-fabrication, Printing, Patterning and Assemblies |
| Editors | G. Forgacs, W. Sun |
| Publisher | Elsevier |
| Pages | 183-216 |
| Number of pages | 34 |
| ISBN (Print) | 9781455728527 |
| DOIs | |
| Publication status | Published - Mar 2013 |
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Keywords
- 3D cell culture
- Additive manufacturing
- Adipose tissue engineering
- Biofabrication
- Biomaterials
- CAD
- CAM
- Co-culture
- HAPC
- Mastectomy
- Preadipocytes
- Scaffold
- Tissue engineering construct
- Vascularization
ASJC Scopus subject areas
- Engineering(all)
Cite this
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Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies. / Chhaya, Mohit P.; Melchels, Ferry P W; Wiggenhauser, Paul S.; Schantz, Jan T.; Hutmacher, Dietmar W.
Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies. ed. / G. Forgacs; W. Sun. Elsevier, 2013. p. 183-216.Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies
AU - Chhaya, Mohit P.
AU - Melchels, Ferry P W
AU - Wiggenhauser, Paul S.
AU - Schantz, Jan T.
AU - Hutmacher, Dietmar W.
PY - 2013/3
Y1 - 2013/3
N2 - Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.
AB - Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.
KW - 3D cell culture
KW - Additive manufacturing
KW - Adipose tissue engineering
KW - Biofabrication
KW - Biomaterials
KW - CAD
KW - CAM
KW - Co-culture
KW - HAPC
KW - Mastectomy
KW - Preadipocytes
KW - Scaffold
KW - Tissue engineering construct
KW - Vascularization
UR - http://www.scopus.com/inward/record.url?scp=84902028451&partnerID=8YFLogxK
U2 - 10.1016/B978-1-4557-2852-7.00010-X
DO - 10.1016/B978-1-4557-2852-7.00010-X
M3 - Chapter
SN - 9781455728527
SP - 183
EP - 216
BT - Biofabrication
A2 - Forgacs, G.
A2 - Sun, W.
PB - Elsevier
ER -