Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies

Mohit P. Chhaya, Ferry P W Melchels, Paul S. Wiggenhauser, Jan T. Schantz, Dietmar W. Hutmacher

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Citations (Scopus)

Abstract

Breast cancer is a major cause of illness for Australian women. Following tumour resection, breast reconstruction is undertaken for cosmetic and psychological reasons. Reconstruction using silicone-based implants leads to complications such as formation of a rigid fibrous tissue surrounding the implant giving a spherical and unnatural appearance to the breast. Reconstruction using autologous tissue is associated with donor site morbidity, tissue resorption and necrosis. Cell-based tissue engineering is an emerging approach to overcome these problems. Fully vascularised adipose tissue can be engineered in vivo with the help of patient-specific bioabsorbable implants fabricated by additive manufacturing. This chapter focuses on a review of such manufacturing techniques and the strategies being developed to engineer long-term fully vascularised and sustainable adipose tissue.

Original languageEnglish
Title of host publicationBiofabrication
Subtitle of host publicationMicro- and Nano-fabrication, Printing, Patterning and Assemblies
EditorsG. Forgacs, W. Sun
PublisherElsevier
Pages183-216
Number of pages34
ISBN (Print)9781455728527
DOIs
Publication statusPublished - Mar 2013

Keywords

  • 3D cell culture
  • Additive manufacturing
  • Adipose tissue engineering
  • Biofabrication
  • Biomaterials
  • CAD
  • CAM
  • Co-culture
  • HAPC
  • Mastectomy
  • Preadipocytes
  • Scaffold
  • Tissue engineering construct
  • Vascularization

ASJC Scopus subject areas

  • Engineering(all)

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