Brain white matter damage in aging and cognitive ability in youth and older age

Maria Del C Valdés Hernández, Tom Booth, Catherine Murray, Alan J Gow, Lars Penke, Zoe Morris, Susana Muñoz Maniega, Natalie A Royle, Benjamin S Aribisala, Mark E Bastin, John M Starr, Ian J Deary, Joanna M Wardlaw

    Research output: Contribution to journalArticlepeer-review

    64 Citations (Scopus)


    Cerebral white matter hyperintensities (WMH) reflect accumulating white matter damage with aging and impair cognition. The role of childhood intelligence is rarely considered in associations between cognitive impairment and WMH. We studied community-dwelling older people all born in 1936, in whom IQ had been assessed at age 11 years. We assessed medical histories, current cognitive ability and quantified WMH on MR imaging. Among 634 participants, mean age 72.7 (SD 0.7), age 11 IQ was the strongest predictor of late life cognitive ability. After accounting for age 11 IQ, greater WMH load was significantly associated with lower late life general cognitive ability (β = -0.14, p < 0.01) and processing speed (β = -0.19, p < 0.001). WMH were also associated independently with lower age 11 IQ (β = -0.08, p < 0.05) and hypertension. In conclusion, having more WMH is significantly associated with lower cognitive ability, after accounting for prior ability, age 11IQ. Early-life IQ also influenced WMH in later life. Determining how lower IQ in youth leads to increasing brain damage with aging is important for future successful cognitive aging.

    Original languageEnglish
    Pages (from-to)2740-2747
    Number of pages8
    JournalNeurobiology of Aging
    Issue number12
    Publication statusPublished - 1 Dec 2013


    • Aged
    • Aging
    • Cerebral Cortex
    • Child
    • Cognition
    • Cognition Disorders
    • Female
    • Humans
    • Intelligence Tests
    • Magnetic Resonance Imaging
    • Male
    • Psychology, Child
    • Risk Factors


    Dive into the research topics of 'Brain white matter damage in aging and cognitive ability in youth and older age'. Together they form a unique fingerprint.

    Cite this