Brain-Eating Amoebae: Predilection Sites in the Brain and Disease Outcome

Timothy Yu Yee Ong; Naveed Ahmed Khan; Ruqaiyyah Siddiqui

doi:10.1128/JCM.02300-16

Brain-Eating Amoebae: Predilection Sites in the Brain and Disease Outcome

Timothy Yu Yee Ong, Naveed Ahmed Khan^*, Ruqaiyyah Siddiqui

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Acanthamoeba spp. and Balamuthia mandrillaris are causative agents of granulomatous amoebic encephalitis (GAE), while Naegleria fowleri causes primary amoebic meningoencephalitis (PAM). PAM is an acute infection that lasts a few days, while GAE is a chronic to subacute infection that can last up to several months. Here, we present a literature review of 86 case reports from 1968 to 2016, in order to explore the affinity of these amoebae for particular sites of the brain, diagnostic modalities, treatment options, and disease outcomes in a comparative manner.

Original language	English
Pages (from-to)	1989-1997
Number of pages	9
Journal	Journal of Clinical Microbiology
Volume	55
Issue number	7
DOIs	https://doi.org/10.1128/JCM.02300-16
Publication status	Published - Jul 2017

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abstract = "Acanthamoeba spp. and Balamuthia mandrillaris are causative agents of granulomatous amoebic encephalitis (GAE), while Naegleria fowleri causes primary amoebic meningoencephalitis (PAM). PAM is an acute infection that lasts a few days, while GAE is a chronic to subacute infection that can last up to several months. Here, we present a literature review of 86 case reports from 1968 to 2016, in order to explore the affinity of these amoebae for particular sites of the brain, diagnostic modalities, treatment options, and disease outcomes in a comparative manner.",

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AB - Acanthamoeba spp. and Balamuthia mandrillaris are causative agents of granulomatous amoebic encephalitis (GAE), while Naegleria fowleri causes primary amoebic meningoencephalitis (PAM). PAM is an acute infection that lasts a few days, while GAE is a chronic to subacute infection that can last up to several months. Here, we present a literature review of 86 case reports from 1968 to 2016, in order to explore the affinity of these amoebae for particular sites of the brain, diagnostic modalities, treatment options, and disease outcomes in a comparative manner.

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Brain-Eating Amoebae: Predilection Sites in the Brain and Disease Outcome

Abstract

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