Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties

Andrew Kellett; Mark O'Connor; Malachy McCann; Mary McNamara; Patrick Lynch; Georgina Rosair; Vickie McKee; Bernie Creaven; Maureen Walsh; Siobhan McClean; Agnieszka Foltyn; Denis O'Shea; Orla Howe; Michael Devereux

doi:10.1039/c0dt01607a

Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties

Andrew Kellett, Mark O'Connor, Malachy McCann, Mary McNamara, Patrick Lynch, Georgina Rosair, Vickie McKee, Bernie Creaven, Maureen Walsh, Siobhan McClean, Agnieszka Foltyn, Denis O'Shea, Orla Howe, Michael Devereux

School of Engineering & Physical Sciences

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Abstract

Three, structurally characterised, bis-phen Cu(ii) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)]₂ and Poly[d(G-C)]₂ binding. © 2011 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	1024-1027
Number of pages	4
Journal	Dalton Transactions
Volume	40
Issue number	5
DOIs	https://doi.org/10.1039/c0dt01607a
Publication status	Published - 7 Feb 2011

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Kellett, A., O'Connor, M., McCann, M., McNamara, M., Lynch, P., Rosair, G., McKee, V., Creaven, B., Walsh, M., McClean, S., Foltyn, A., O'Shea, D., Howe, O., & Devereux, M. (2011). Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties. Dalton Transactions, 40(5), 1024-1027. https://doi.org/10.1039/c0dt01607a

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abstract = "Three, structurally characterised, bis-phen Cu(ii) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)]2 and Poly[d(G-C)]2 binding. {\textcopyright} 2011 The Royal Society of Chemistry.",

author = "Andrew Kellett and Mark O'Connor and Malachy McCann and Mary McNamara and Patrick Lynch and Georgina Rosair and Vickie McKee and Bernie Creaven and Maureen Walsh and Siobhan McClean and Agnieszka Foltyn and Denis O'Shea and Orla Howe and Michael Devereux",

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Kellett, A, O'Connor, M, McCann, M, McNamara, M, Lynch, P, Rosair, G, McKee, V, Creaven, B, Walsh, M, McClean, S, Foltyn, A, O'Shea, D, Howe, O & Devereux, M 2011, 'Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties', Dalton Transactions, vol. 40, no. 5, pp. 1024-1027. https://doi.org/10.1039/c0dt01607a

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T1 - Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties

AU - Kellett, Andrew

AU - O'Connor, Mark

AU - McCann, Malachy

AU - McNamara, Mary

AU - Lynch, Patrick

AU - Rosair, Georgina

AU - McKee, Vickie

AU - Creaven, Bernie

AU - Walsh, Maureen

AU - McClean, Siobhan

AU - Foltyn, Agnieszka

AU - O'Shea, Denis

AU - Howe, Orla

AU - Devereux, Michael

PY - 2011/2/7

Y1 - 2011/2/7

N2 - Three, structurally characterised, bis-phen Cu(ii) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)]2 and Poly[d(G-C)]2 binding. © 2011 The Royal Society of Chemistry.

AB - Three, structurally characterised, bis-phen Cu(ii) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)]2 and Poly[d(G-C)]2 binding. © 2011 The Royal Society of Chemistry.

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U2 - 10.1039/c0dt01607a

DO - 10.1039/c0dt01607a

M3 - Article

SN - 1477-9226

VL - 40

SP - 1024

EP - 1027

JO - Dalton Transactions

JF - Dalton Transactions

IS - 5

ER -

Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties

Abstract

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