Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties

Andrew Kellett, Mark O'Connor, Malachy McCann, Mary McNamara, Patrick Lynch, Georgina Rosair, Vickie McKee, Bernie Creaven, Maureen Walsh, Siobhan McClean, Agnieszka Foltyn, Denis O'Shea, Orla Howe, Michael Devereux

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Three, structurally characterised, bis-phen Cu(ii) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)]2 and Poly[d(G-C)]2 binding. © 2011 The Royal Society of Chemistry.

Original languageEnglish
Pages (from-to)1024-1027
Number of pages4
JournalDalton Transactions
Volume40
Issue number5
DOIs
Publication statusPublished - 7 Feb 2011

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