Bioinspired Porous ZnO Nanomaterials from Fungal Polysaccharides: Advanced Materials with Unprecedented Low Toxicity in Vitro for Human Cells

Chunping Xu; Manuel Ojeda; Rick A. D. Arancon; Antonio A. Romero; Jose Luis Domingo; Mercedes Gomez; Jordi Blanco; Rafael Luque

doi:10.1021/acssuschemeng.5b00568

Bioinspired Porous ZnO Nanomaterials from Fungal Polysaccharides: Advanced Materials with Unprecedented Low Toxicity in Vitro for Human Cells

Chunping Xu, Manuel Ojeda, Rick A. D. Arancon, Antonio A. Romero, Jose Luis Domingo, Mercedes Gomez, Jordi Blanco, Rafael Luque^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Mechanochemically synthesized ZnO-polysaccharide nanohybrids prepared from fungal polysaccharides were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized ZnO nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SYSY (EC50: 50-100 mu g mL(-1)) as compared to commercial ZnO nanomaterials due to the stability and low release of Zn2+ and reduced interaction nanoparticle/cells due to the high biocompatibility of the nanohybrids.

Original language	English
Pages (from-to)	2716-2725
Number of pages	10
Journal	ACS Sustainable Chemistry and Engineering
Volume	3
Issue number	11
DOIs	https://doi.org/10.1021/acssuschemeng.5b00568
Publication status	Published - 2 Nov 2015

Keywords

ZnO
Mechanochemistry
Cytotoxicity
Bionanomaterials
ZINC-OXIDE NANOPARTICLES
ULTRAFINE PARTICLES
SURFACE-PROPERTIES
XPS-SPECTRA
THIN-FILMS
CYTOTOXICITY
ION
GENOTOXICITY
MECHANOCHEMISTRY
TRANSFORMATIONS

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title = "Bioinspired Porous ZnO Nanomaterials from Fungal Polysaccharides: Advanced Materials with Unprecedented Low Toxicity in Vitro for Human Cells",

abstract = "Mechanochemically synthesized ZnO-polysaccharide nanohybrids prepared from fungal polysaccharides were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized ZnO nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SYSY (EC50: 50-100 mu g mL(-1)) as compared to commercial ZnO nanomaterials due to the stability and low release of Zn2+ and reduced interaction nanoparticle/cells due to the high biocompatibility of the nanohybrids.",

keywords = "ZnO, Mechanochemistry, Cytotoxicity, Bionanomaterials, ZINC-OXIDE NANOPARTICLES, ULTRAFINE PARTICLES, SURFACE-PROPERTIES, XPS-SPECTRA, THIN-FILMS, CYTOTOXICITY, ION, GENOTOXICITY, MECHANOCHEMISTRY, TRANSFORMATIONS",

author = "Chunping Xu and Manuel Ojeda and Arancon, {Rick A. D.} and Romero, {Antonio A.} and Domingo, {Jose Luis} and Mercedes Gomez and Jordi Blanco and Rafael Luque",

year = "2015",

month = nov,

day = "2",

doi = "10.1021/acssuschemeng.5b00568",

language = "English",

volume = "3",

pages = "2716--2725",

journal = "ACS Sustainable Chemistry and Engineering",

issn = "2168-0485",

publisher = "American Chemical Society",

number = "11",

}

TY - JOUR

T1 - Bioinspired Porous ZnO Nanomaterials from Fungal Polysaccharides

T2 - Advanced Materials with Unprecedented Low Toxicity in Vitro for Human Cells

AU - Xu, Chunping

AU - Ojeda, Manuel

AU - Arancon, Rick A. D.

AU - Romero, Antonio A.

AU - Domingo, Jose Luis

AU - Gomez, Mercedes

AU - Blanco, Jordi

AU - Luque, Rafael

PY - 2015/11/2

Y1 - 2015/11/2

N2 - Mechanochemically synthesized ZnO-polysaccharide nanohybrids prepared from fungal polysaccharides were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized ZnO nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SYSY (EC50: 50-100 mu g mL(-1)) as compared to commercial ZnO nanomaterials due to the stability and low release of Zn2+ and reduced interaction nanoparticle/cells due to the high biocompatibility of the nanohybrids.

AB - Mechanochemically synthesized ZnO-polysaccharide nanohybrids prepared from fungal polysaccharides were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized ZnO nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SYSY (EC50: 50-100 mu g mL(-1)) as compared to commercial ZnO nanomaterials due to the stability and low release of Zn2+ and reduced interaction nanoparticle/cells due to the high biocompatibility of the nanohybrids.

KW - ZnO

KW - Mechanochemistry

KW - Cytotoxicity

KW - Bionanomaterials

KW - ZINC-OXIDE NANOPARTICLES

KW - ULTRAFINE PARTICLES

KW - SURFACE-PROPERTIES

KW - XPS-SPECTRA

KW - THIN-FILMS

KW - CYTOTOXICITY

KW - ION

KW - GENOTOXICITY

KW - MECHANOCHEMISTRY

KW - TRANSFORMATIONS

U2 - 10.1021/acssuschemeng.5b00568

DO - 10.1021/acssuschemeng.5b00568

M3 - Article

SN - 2168-0485

VL - 3

SP - 2716

EP - 2725

JO - ACS Sustainable Chemistry and Engineering

JF - ACS Sustainable Chemistry and Engineering

IS - 11

ER -

Bioinspired Porous ZnO Nanomaterials from Fungal Polysaccharides: Advanced Materials with Unprecedented Low Toxicity in Vitro for Human Cells

Abstract

Keywords

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