Biofluid behaviour in 3D microchannel systems: Numerical analysis and design development of 3D microchannel biochip separators

Xiangdong Xue, Silvia Marson, Mayur K. Patel, Usama M. Attia, Chris Bailey, William O'Neill, David Topham, M. P Y Desmulliez

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This paper describes the design and development cycle of a 3D biochip separator and the modelling analysis of flow behaviour in the biochip microchannel features. The focus is on identifying the difference between 2D and 3D implementations as well as developing basic forms of 3D microfluidic separators. Five variants, based around the device are proposed and analysed. These include three variations of the branch channels (circular, rectangular, disc) and two variations of the main channel (solid and concentric). Ignoring the initial transient behaviour and assuming steady state flow has been established, the efficiencies of the flow between the main and side channels for the different designs are analysed and compared with regard to relevant biomicrofluidic laws or effects (bifurcation law, Fahraeus effect, cell-free phenomenon, bending channel effect and laminar flow behaviour). The modelling results identify flow features in microchannels, a constriction and bifurcations and show detailed differences in flow fields between the various designs. The manufacturing process using injection moulding for the initial base case design is also presented and discussed. The work reported here is supported as part of the UK funded 3D-MINTEGRATION project. © 2010 IEEE.

Original languageEnglish
Title of host publication2010 Proceedings 60th Electronic Components and Technology Conference, ECTC 2010
Pages1021-1030
Number of pages10
DOIs
Publication statusPublished - 2010
Event60th Electronic Components and Technology Conference - Las Vegas, NV, United States
Duration: 1 Jun 20104 Jun 2010

Conference

Conference60th Electronic Components and Technology Conference
Abbreviated titleECTC 2010
CountryUnited States
CityLas Vegas, NV
Period1/06/104/06/10

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    Xue, X., Marson, S., Patel, M. K., Attia, U. M., Bailey, C., O'Neill, W., Topham, D., & Desmulliez, M. P. Y. (2010). Biofluid behaviour in 3D microchannel systems: Numerical analysis and design development of 3D microchannel biochip separators. In 2010 Proceedings 60th Electronic Components and Technology Conference, ECTC 2010 (pp. 1021-1030) https://doi.org/10.1109/ECTC.2010.5490827