Behavioral and Electrophysiological Correlates of Memory Binding Deficits in Patients at Different Risk Levels for Alzheimer's Disease

Marcos Pietto, Mario Parra Rodriguez, Natalia Trujillo, Facundo Flores, Adolfo M. García, Julian Bustin, Pablo Richly, Facundo Manes, Francisco Lopera, Agustín M. Ibáñez, Sandra Baez

Research output: Contribution to journalArticle

Abstract

Deficits in visual short-term memory (VSTM) binding have been proposed as an early and specific marker for Alzheimer's disease (AD). However, no studies have explored the neural correlates of this domain in clinical categories involving prodromal stages with different risk levels of conversion to AD. We assessed underlying electrophysiological modulations in patients with mild cognitive impairment (MCI), patients in the MCI stages of familial AD carrying the mutation E280A of the presenilin-1 gene (MCI-FAD), and healthy controls. Moreover, we compared the behavioral performance and neural correlates of both patient groups. Participants completed a change-detection VSTM task assessing recognition of changes between shapes or shape-color bindings, presented in two consecutive arrays (i.e., study and test) while event related potentials (ERPs) were recorded. Changes always occurred in the test array and consisted of new features replacing studied features (shape-only) or features swapping across items (shape-color binding). Both MCI and MCI-FAD patients performed worse than controls in the shape-color binding condition. Early electrophysiological activity (100250ms) was significantly reduced in both clinical groups, particularly over fronto-central and parieto-occipital regions. However, shape-color binding performance and their reduced neural correlates were similar between MCI and MCI-FAD. Our results support the validity of the VSTM binding test and their neural correlates in the early detection of AD and highlight the importance of studies comparing samples at different risk for AD conversion. The combined analysis of behavioral and ERP data gleaned with the VSTM binding task can offer a valuable memory biomarker for AD.

Original languageEnglish
Pages (from-to)1325-1340
Number of pages16
JournalJournal of Alzheimer's Disease
Volume53
Issue number4
DOIs
StatePublished - 8 Aug 2016

Fingerprint

Mild Cognitive Impairment
Memory Disorders
Alzheimer Disease
Short-Term Memory
Color
Flavin-Adenine Dinucleotide
Evoked Potentials
Presenilin-1
Prodromal Symptoms
Occipital Lobe
Reproducibility of Results
Early Diagnosis
Biological Markers
Mutation
Genes
Recognition (Psychology)

Keywords

  • Electroencephalogram (EEG)
  • Event related potentials (ERPs)
  • Familial Alzheimer's disease
  • Memory binding
  • Mild cognitive impairment
  • Short-term memory

Cite this

Pietto, Marcos; Parra Rodriguez, Mario; Trujillo, Natalia; Flores, Facundo; García, Adolfo M.; Bustin, Julian; Richly, Pablo; Manes, Facundo; Lopera, Francisco; Ibáñez, Agustín M.; Baez, Sandra / Behavioral and Electrophysiological Correlates of Memory Binding Deficits in Patients at Different Risk Levels for Alzheimer's Disease.

In: Journal of Alzheimer's Disease, Vol. 53, No. 4, 08.08.2016, p. 1325-1340.

Research output: Contribution to journalArticle

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Pietto, M, Parra Rodriguez, M, Trujillo, N, Flores, F, García, AM, Bustin, J, Richly, P, Manes, F, Lopera, F, Ibáñez, AM & Baez, S 2016, 'Behavioral and Electrophysiological Correlates of Memory Binding Deficits in Patients at Different Risk Levels for Alzheimer's Disease' Journal of Alzheimer's Disease, vol 53, no. 4, pp. 1325-1340. DOI: 10.3233/JAD-160056

Behavioral and Electrophysiological Correlates of Memory Binding Deficits in Patients at Different Risk Levels for Alzheimer's Disease. / Pietto, Marcos; Parra Rodriguez, Mario; Trujillo, Natalia; Flores, Facundo; García, Adolfo M.; Bustin, Julian; Richly, Pablo; Manes, Facundo; Lopera, Francisco; Ibáñez, Agustín M.; Baez, Sandra.

In: Journal of Alzheimer's Disease, Vol. 53, No. 4, 08.08.2016, p. 1325-1340.

Research output: Contribution to journalArticle

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AU - Pietto,Marcos

AU - Parra Rodriguez,Mario

AU - Trujillo,Natalia

AU - Flores,Facundo

AU - García,Adolfo M.

AU - Bustin,Julian

AU - Richly,Pablo

AU - Manes,Facundo

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AU - Ibáñez,Agustín M.

AU - Baez,Sandra

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