Bayesian Spectrum Analysis of Non-Linear Ultrasound Contrast Microbubble Signals

Konstantinos Diamantis, James R. Hopgood, Vassilis Sboros

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)
49 Downloads (Pure)


The localization of individual contrast microbubbles (MBs)is key to the emerging field of super-resolution ultrasound. The Fourier Transform (FT)is typically used for the frequency domain analysis of MB signals in ultrasound contrast imaging. Bayesian spectrum analysis offers a viable solution to overcome the limited frequency resolution achieved by the FT for MB scatterers. A typical MB signal sampled at 20 MHz and consisting of approximately 80 samples was investigated. The conventional frequency resolution for Fourier-based methods in this instance was 241 kHz. The Bayesian spectral estimation resulted in 12 distinct frequency components many of which were separated by less than 241 kHz. The smallest separation was 52 kHz. The resulting frequency and amplitude estimates matched relatively well with the Fast Fourier Transform (FFT)spectral peaks. Using these estimates the MB signal was reconstructed, and a correlation coefficient of approximately 0.99 was achieved between original and reconstructed signals. The result was reproduced in the analysis of a synthetic MB signal, similar to the original one, and all 12 frequencies were always resolved. Overall, the method promises high spectral resolution without sacrificing the temporal one, and provides information that may be used to differentiate the MB non-linear signal from that of linear scatterers.

Original languageEnglish
Title of host publication2018 IEEE International Ultrasonics Symposium (IUS)
ISBN (Electronic)9781538634257
Publication statusPublished - 20 Dec 2018
Event2018 IEEE International Ultrasonics Symposium - Kobe, Japan
Duration: 22 Oct 201825 Oct 2018

Publication series

NameIEEE International Ultrasonics Symposium (IUS)
ISSN (Electronic)1948-5727


Conference2018 IEEE International Ultrasonics Symposium
Abbreviated titleIUS 2018

ASJC Scopus subject areas

  • Acoustics and Ultrasonics


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