Bayesian based similarity assessment of nanomaterials to inform grouping

Georgia Tsiliki, Didem Ag Seleci, Alex Zabeo, Gianpietro Basei, Danail Hristozov, Nina Jeliazkova, Matthew Boyles, Fiona Murphy, Willie J. G. M. Peijnenburg, Wendel Wohlleben, Vicki Stone

Research output: Contribution to journalArticlepeer-review

Abstract

Nanoforms can be manufactured in plenty of variants by differing their physicochemical properties and toxicokinetic behaviour which can affect their hazard potential. To avoid testing of each single nanomaterial and nanoform variation and subsequently save resources, grouping and read-across strategies are used to estimate groups of substances, based on carefully selected evidence, that could potentially have similar human health and environmental hazard impact. A novel computational similarity method is presented aiming to compare dose-response curves and identify sets of similar nanoforms. The suggested method estimates the statistical model that best fits the data by leveraging pairwise Bayes Factor analysis to compare pairs of curves and evaluate whether each of the nanoforms is sufficiently similar to all other nanoforms. Pairwise comparisons to benchmark materials are used to define threshold similarity values and set the criteria for identifying groups of nanoforms with comparatively similar toxicity. Applications to use case data are shown to demonstrate that the method can support grouping hypotheses linked to a certain hazard endpoint and route of exposure.

Original languageEnglish
Article number100389
JournalNanoImpact
Volume25
Early online date5 Feb 2022
DOIs
Publication statusPublished - 17 Feb 2022

Keywords

  • Biological relevance
  • Dose-response data
  • Grouping
  • Pairwise comparisons
  • Similarity

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Safety, Risk, Reliability and Quality
  • Safety Research
  • Materials Science (miscellaneous)

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