Bacterial Attachment to Polymeric Materials Correlates with Molecular Flexibility and Hydrophilicity

Olutoba Sanni, Chien-Yi Chang, Daniel G. Anderson, Robert Langer, Martyn C. Davies, Philip M. Williams, Paul Williams, Morgan R. Alexander, Andrew L. Hook*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    54 Citations (Scopus)


    A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria is explored, comparing cyclic, aromatic, and linear chemical groups. A correlation is shown between bacterial attachment and a parameter derived from the partition coefficient and the number of rotatable bonds of the materials' pendant groups. This correlation is applicable to 86% of the hydrocarbon pendant moieties surveyed, quantitatively supporting the previous qualitative observation that bacteria are repelled from poly(meth)acrylates containing a hydrophilic ester group when the pendant group is both rigid and hydrophobic. This insight will help inform and predict the further development of polymers resistant to bacterial attachment.

    Original languageEnglish
    Pages (from-to)695-701
    Number of pages7
    JournalAdvanced Healthcare Materials
    Issue number5
    Publication statusPublished - 2 Apr 2015


    • Pseudomonas aeruginosa
    • Ion mass spectrometry
    • Low-fouling
    • Molecular descriptors
    • Polymer microarrays

    ASJC Scopus subject areas

    • Biomedical Engineering
    • Biomaterials
    • Pharmaceutical Science


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