Bacillus subtilis AB1 controls Aeromonas infection in rainbow trout (Oncorhynchus mykiss, Walbaum)

A. Newaj-Fyzul, A. A. Adesiyun, A. Mutani, A. Ramsubhag, J. Brunt, B. Austin

    Research output: Contribution to journalArticle

    Abstract

    Aim: To develop a probiotic with effectiveness against Aeromonas sp., which was pathogenic to rainbow trout. Methods and Results: When Bacillus subtilis AB1, which was obtained from fish intestine, was administered for 14 days to rainbow trout in feed at a concentration of 107 cells per gram either as viable, formalized or sonicated cells or as cell-free supernatant, the fish survived challenge with the pathogen. AB1 stimulated immune parameters, specifically stimulating respiratory burst, serum and gut lysozyme, peroxidase, phagocytic killing, total and a1-antiprotease and lymphocyte populations. Conclusions: Bacillus subtilis AB1 was effective as a probiotic at controlling infections by a fish-pathogenic Aeromonas sp. in rainbow trout. Significance and Impact of the Study: Disease control in fish is possible by means of the oral application of live and inactivated cells and their subcellular components with the mode of action reflecting stimulation of the innate immune response. © 2007 The Authors.

    Original languageEnglish
    Pages (from-to)1699-1706
    Number of pages8
    JournalJournal of Applied Microbiology
    Volume103
    Issue number5
    DOIs
    Publication statusPublished - Nov 2007

    Fingerprint

    Aeromonas
    Oncorhynchus mykiss
    Infection Control
    Bacillus subtilis
    Fishes
    Probiotics
    Respiratory Burst
    Muramidase
    Protease Inhibitors
    Innate Immunity
    Peroxidase
    Intestines
    Lymphocytes
    Infection
    Serum
    Population

    Keywords

    • Aeromonas
    • Bacillus subtilis AB1
    • Fish disease
    • Innate immunity
    • Probiotic
    • Specific immunity

    Cite this

    Newaj-Fyzul, A. ; Adesiyun, A. A. ; Mutani, A. ; Ramsubhag, A. ; Brunt, J. ; Austin, B. / Bacillus subtilis AB1 controls Aeromonas infection in rainbow trout (Oncorhynchus mykiss, Walbaum). In: Journal of Applied Microbiology. 2007 ; Vol. 103, No. 5. pp. 1699-1706.
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    Newaj-Fyzul, A, Adesiyun, AA, Mutani, A, Ramsubhag, A, Brunt, J & Austin, B 2007, 'Bacillus subtilis AB1 controls Aeromonas infection in rainbow trout (Oncorhynchus mykiss, Walbaum)', Journal of Applied Microbiology, vol. 103, no. 5, pp. 1699-1706. https://doi.org/10.1111/j.1365-2672.2007.03402.x

    Bacillus subtilis AB1 controls Aeromonas infection in rainbow trout (Oncorhynchus mykiss, Walbaum). / Newaj-Fyzul, A.; Adesiyun, A. A.; Mutani, A.; Ramsubhag, A.; Brunt, J.; Austin, B.

    In: Journal of Applied Microbiology, Vol. 103, No. 5, 11.2007, p. 1699-1706.

    Research output: Contribution to journalArticle

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    AU - Newaj-Fyzul, A.

    AU - Adesiyun, A. A.

    AU - Mutani, A.

    AU - Ramsubhag, A.

    AU - Brunt, J.

    AU - Austin, B.

    PY - 2007/11

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    N2 - Aim: To develop a probiotic with effectiveness against Aeromonas sp., which was pathogenic to rainbow trout. Methods and Results: When Bacillus subtilis AB1, which was obtained from fish intestine, was administered for 14 days to rainbow trout in feed at a concentration of 107 cells per gram either as viable, formalized or sonicated cells or as cell-free supernatant, the fish survived challenge with the pathogen. AB1 stimulated immune parameters, specifically stimulating respiratory burst, serum and gut lysozyme, peroxidase, phagocytic killing, total and a1-antiprotease and lymphocyte populations. Conclusions: Bacillus subtilis AB1 was effective as a probiotic at controlling infections by a fish-pathogenic Aeromonas sp. in rainbow trout. Significance and Impact of the Study: Disease control in fish is possible by means of the oral application of live and inactivated cells and their subcellular components with the mode of action reflecting stimulation of the innate immune response. © 2007 The Authors.

    AB - Aim: To develop a probiotic with effectiveness against Aeromonas sp., which was pathogenic to rainbow trout. Methods and Results: When Bacillus subtilis AB1, which was obtained from fish intestine, was administered for 14 days to rainbow trout in feed at a concentration of 107 cells per gram either as viable, formalized or sonicated cells or as cell-free supernatant, the fish survived challenge with the pathogen. AB1 stimulated immune parameters, specifically stimulating respiratory burst, serum and gut lysozyme, peroxidase, phagocytic killing, total and a1-antiprotease and lymphocyte populations. Conclusions: Bacillus subtilis AB1 was effective as a probiotic at controlling infections by a fish-pathogenic Aeromonas sp. in rainbow trout. Significance and Impact of the Study: Disease control in fish is possible by means of the oral application of live and inactivated cells and their subcellular components with the mode of action reflecting stimulation of the innate immune response. © 2007 The Authors.

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