Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging

Antonios Perperidis; David Thomas; Michalakis Averkiou; Colin Duncan; Alan McNeilly; Mairead Butler; Vassilis Sboros

doi:10.1109/EMBC.2014.6944766

Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging

Antonios Perperidis^*, David Thomas, Michalakis Averkiou, Colin Duncan, Alan McNeilly, Mairead Butler, Vassilis Sboros

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Citations (Scopus)

Abstract

Microvasculature density (MVD) provides an established biomarker for the prognosis of numerous diseases associated with abnormal microvascular networks. The accurate, robust and timely assessment of MVD changes facilitates disease detection, treatment monitoring and patient stratification. Nevertheless, the current gold standard (PET) for MVD quantification is not used in clinical practice due to its high costs and potential health hazards. Contrast Enhanced Ultrasound (CEUS) imaging can provide an attractive alternative. However, the limited dissociation between larger vessels and microvasculature in the imaged tissues limits the accuracy and robustness of CEUS. This study proposed a novel, and fully automatic technique that dissociates larger vessels from microvasculature in CEUS imaged tissues. The ovine Corpus Luteum (CL) was used as an in vivo model for the development and assessment of the proposed technique.

Original language	English
Title of host publication	2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Place of Publication	New York
Publisher	IEEE
Pages	5076-5079
Number of pages	4
DOIs	https://doi.org/10.1109/EMBC.2014.6944766
Publication status	Published - 2014
Event	36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society - Chicago, Israel Duration: 26 Aug 2014 → 30 Aug 2014

Publication series

Name	IEEE Engineering in Medicine and Biology Society Conference Proceedings
Publisher	IEEE
ISSN (Print)	1557-170X

Conference

Conference	36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society
Abbreviated title	EMBC
Country/Territory	Israel
Period	26/08/14 → 30/08/14

Keywords

CORPUS-LUTEUM
QUANTIFICATION
ECHOCARDIOGRAPHY
PERFUSION
AGENTS

Access to Document

10.1109/EMBC.2014.6944766

Cite this

Perperidis, A., Thomas, D., Averkiou, M., Duncan, C., McNeilly, A., Butler, M., & Sboros, V. (2014). Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 5076-5079). (IEEE Engineering in Medicine and Biology Society Conference Proceedings). IEEE. https://doi.org/10.1109/EMBC.2014.6944766

Perperidis, Antonios ; Thomas, David ; Averkiou, Michalakis et al. / Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging. 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). New York : IEEE, 2014. pp. 5076-5079 (IEEE Engineering in Medicine and Biology Society Conference Proceedings).

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title = "Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging",

abstract = "Microvasculature density (MVD) provides an established biomarker for the prognosis of numerous diseases associated with abnormal microvascular networks. The accurate, robust and timely assessment of MVD changes facilitates disease detection, treatment monitoring and patient stratification. Nevertheless, the current gold standard (PET) for MVD quantification is not used in clinical practice due to its high costs and potential health hazards. Contrast Enhanced Ultrasound (CEUS) imaging can provide an attractive alternative. However, the limited dissociation between larger vessels and microvasculature in the imaged tissues limits the accuracy and robustness of CEUS. This study proposed a novel, and fully automatic technique that dissociates larger vessels from microvasculature in CEUS imaged tissues. The ovine Corpus Luteum (CL) was used as an in vivo model for the development and assessment of the proposed technique.",

keywords = "CORPUS-LUTEUM, QUANTIFICATION, ECHOCARDIOGRAPHY, PERFUSION, AGENTS",

author = "Antonios Perperidis and David Thomas and Michalakis Averkiou and Colin Duncan and Alan McNeilly and Mairead Butler and Vassilis Sboros",

year = "2014",

doi = "10.1109/EMBC.2014.6944766",

language = "English",

series = "IEEE Engineering in Medicine and Biology Society Conference Proceedings",

publisher = "IEEE",

pages = "5076--5079",

booktitle = "2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)",

address = "United States",

note = "36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, EMBC ; Conference date: 26-08-2014 Through 30-08-2014",

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Perperidis, A, Thomas, D, Averkiou, M, Duncan, C, McNeilly, A, Butler, M & Sboros, V 2014, Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging. in 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE Engineering in Medicine and Biology Society Conference Proceedings, IEEE, New York, pp. 5076-5079, 36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society, Israel, 26/08/14. https://doi.org/10.1109/EMBC.2014.6944766

Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging. / Perperidis, Antonios; Thomas, David; Averkiou, Michalakis et al.
2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). New York: IEEE, 2014. p. 5076-5079 (IEEE Engineering in Medicine and Biology Society Conference Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging

AU - Perperidis, Antonios

AU - Thomas, David

AU - Averkiou, Michalakis

AU - Duncan, Colin

AU - McNeilly, Alan

AU - Butler, Mairead

AU - Sboros, Vassilis

PY - 2014

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N2 - Microvasculature density (MVD) provides an established biomarker for the prognosis of numerous diseases associated with abnormal microvascular networks. The accurate, robust and timely assessment of MVD changes facilitates disease detection, treatment monitoring and patient stratification. Nevertheless, the current gold standard (PET) for MVD quantification is not used in clinical practice due to its high costs and potential health hazards. Contrast Enhanced Ultrasound (CEUS) imaging can provide an attractive alternative. However, the limited dissociation between larger vessels and microvasculature in the imaged tissues limits the accuracy and robustness of CEUS. This study proposed a novel, and fully automatic technique that dissociates larger vessels from microvasculature in CEUS imaged tissues. The ovine Corpus Luteum (CL) was used as an in vivo model for the development and assessment of the proposed technique.

AB - Microvasculature density (MVD) provides an established biomarker for the prognosis of numerous diseases associated with abnormal microvascular networks. The accurate, robust and timely assessment of MVD changes facilitates disease detection, treatment monitoring and patient stratification. Nevertheless, the current gold standard (PET) for MVD quantification is not used in clinical practice due to its high costs and potential health hazards. Contrast Enhanced Ultrasound (CEUS) imaging can provide an attractive alternative. However, the limited dissociation between larger vessels and microvasculature in the imaged tissues limits the accuracy and robustness of CEUS. This study proposed a novel, and fully automatic technique that dissociates larger vessels from microvasculature in CEUS imaged tissues. The ovine Corpus Luteum (CL) was used as an in vivo model for the development and assessment of the proposed technique.

KW - CORPUS-LUTEUM

KW - QUANTIFICATION

KW - ECHOCARDIOGRAPHY

KW - PERFUSION

KW - AGENTS

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DO - 10.1109/EMBC.2014.6944766

M3 - Conference contribution

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BT - 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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ER -

Perperidis A, Thomas D, Averkiou M, Duncan C, McNeilly A, Butler M et al. Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging. In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). New York: IEEE. 2014. p. 5076-5079. (IEEE Engineering in Medicine and Biology Society Conference Proceedings). doi: 10.1109/EMBC.2014.6944766

Automatic dissociation between microvasculature and larger vessels for ultrasound contrast imaging

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Keywords

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