Atherosclerosis and vasomotor dysfunction in arteries of animals after exposure to combustion-derived particulate matter or nanomaterials

Peter Møller, Daniel Vest Christophersen, Nicklas Raun Jacobsen, Astrid Skovmand, Ana Cecília Damião Gouveia, Maria Helena Guerra Andersen, Ali Kermanizadeh, Ditte Marie Jensen, Pernille Høgh Danielsen, Martin Roursgaard, Kim Jantzen, Steffen Loft

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)


Exposure to particulate matter (PM) from traffic vehicles is hazardous to the vascular system, leading to clinical manifestations and mortality due to ischemic heart disease. By analogy, nanomaterials may also be associated with the same outcomes. Here, the effects of exposure to PM from ambient air, diesel exhaust and certain nanomaterials on atherosclerosis and vasomotor function in animals have been assessed. The majority of studies have used pulmonary exposure by inhalation or instillation, although there are some studies on non-pulmonary routes such as the gastrointestinal tract. Airway exposure to air pollution particles and nanomaterials is associated with similar effects on atherosclerosis progression, augmented vasoconstriction and blunted vasorelaxation responses in arteries, whereas exposure to diesel exhaust is associated with lower responses. At present, there is no convincing evidence of dose-dependent effects across studies. Oxidative stress and inflammation have been observed in the arterial wall of PM-exposed animals with vasomotor dysfunction or plaque progression. From the data, it is evident that pulmonary and systemic inflammation does not seem to be necessary for these vascular effects to occur. Furthermore, there is inconsistent evidence with regard to altered plasma lipid profile and systemic inflammation as a key step in vasomotor dysfunction and progression of atherosclerosis in PM-exposed animals. In summary, the results show that certain nanomaterials, including TiO2, carbon black and carbon nanotubes, have similar hazards to the vascular system as combustion-derived PM.

Original languageEnglish
Pages (from-to)437-476
Number of pages40
JournalCritical Reviews in Toxicology
Issue number5
Publication statusPublished - 30 Mar 2016


  • Animals
  • Atherosclerosis/chemically induced
  • Humans
  • Nanostructures/toxicity
  • Particulate Matter/poisoning
  • Vasomotor System/drug effects


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