Association of existing and new candidate genes for anxiety, depression and personality traits in older people

Michelle Luciano, Lorna M. Houlihan, Sarah E. Harris, Alan J. Gow, Caroline Hayward, John M. Starr, Ian J. Deary

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)

    Abstract

    Genetic variants that have previously been associated with personality traits and/or psychological distress, or inflammatory marker levels were investigated for their relationship to self-rated personality traits, anxiety, and depression in two elderly Scottish cohorts. Ten genes (29 SNPs) were investigated in the Lothian Birth Cohort 1936 (similar to 70 years, N = 1,091). Four of these genes and seven others (35 SNPs) were tested in the Lothian Birth Cohort 1921 who were measured on the same traits and states on two occasions (similar to 80 years, N = 550; 87 years, N = 229). For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. Of the inflammatory marker candidate genes, TF showed some association with psychological distress. No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality.

    Original languageEnglish
    Pages (from-to)518-532
    Number of pages15
    JournalBehavior Genetics
    Volume40
    Issue number4
    DOIs
    Publication statusPublished - Jul 2010

    Keywords

    • onset
    • Candidate genes
    • Depression
    • Nitric-oxide synthase
    • Anxiety
    • PRESENILIN-1 GENE
    • Personality
    • M2 CHRM2 GENE
    • COMT
    • Genetic association
    • disorder
    • Alzheimers disease
    • intronic polymorphism
    • population
    • Inflammatory marker genes
    • functional polymorphism

    Cite this