Association of existing and new candidate genes for anxiety, depression and personality traits in older people

Michelle Luciano; Lorna M. Houlihan; Sarah E. Harris; Alan J. Gow; Caroline Hayward; John M. Starr; Ian J. Deary

doi:10.1007/s10519-009-9326-4

Association of existing and new candidate genes for anxiety, depression and personality traits in older people

Michelle Luciano^*, Lorna M. Houlihan, Sarah E. Harris, Alan J. Gow, Caroline Hayward, John M. Starr, Ian J. Deary

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Genetic variants that have previously been associated with personality traits and/or psychological distress, or inflammatory marker levels were investigated for their relationship to self-rated personality traits, anxiety, and depression in two elderly Scottish cohorts. Ten genes (29 SNPs) were investigated in the Lothian Birth Cohort 1936 (similar to 70 years, N = 1,091). Four of these genes and seven others (35 SNPs) were tested in the Lothian Birth Cohort 1921 who were measured on the same traits and states on two occasions (similar to 80 years, N = 550; 87 years, N = 229). For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. Of the inflammatory marker candidate genes, TF showed some association with psychological distress. No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality.

Original language	English
Pages (from-to)	518-532
Number of pages	15
Journal	Behavior Genetics
Volume	40
Issue number	4
DOIs	https://doi.org/10.1007/s10519-009-9326-4
Publication status	Published - Jul 2010

Keywords

onset
Candidate genes
Depression
Nitric-oxide synthase
Anxiety
PRESENILIN-1 GENE
Personality
M2 CHRM2 GENE
COMT
Genetic association
disorder
Alzheimers disease
intronic polymorphism
population
Inflammatory marker genes
functional polymorphism

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title = "Association of existing and new candidate genes for anxiety, depression and personality traits in older people",

abstract = "Genetic variants that have previously been associated with personality traits and/or psychological distress, or inflammatory marker levels were investigated for their relationship to self-rated personality traits, anxiety, and depression in two elderly Scottish cohorts. Ten genes (29 SNPs) were investigated in the Lothian Birth Cohort 1936 (similar to 70 years, N = 1,091). Four of these genes and seven others (35 SNPs) were tested in the Lothian Birth Cohort 1921 who were measured on the same traits and states on two occasions (similar to 80 years, N = 550; 87 years, N = 229). For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. Of the inflammatory marker candidate genes, TF showed some association with psychological distress. No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality.",

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author = "Michelle Luciano and Houlihan, {Lorna M.} and Harris, {Sarah E.} and Gow, {Alan J.} and Caroline Hayward and Starr, {John M.} and Deary, {Ian J.}",

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AU - Hayward, Caroline

AU - Starr, John M.

AU - Deary, Ian J.

PY - 2010/7

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N2 - Genetic variants that have previously been associated with personality traits and/or psychological distress, or inflammatory marker levels were investigated for their relationship to self-rated personality traits, anxiety, and depression in two elderly Scottish cohorts. Ten genes (29 SNPs) were investigated in the Lothian Birth Cohort 1936 (similar to 70 years, N = 1,091). Four of these genes and seven others (35 SNPs) were tested in the Lothian Birth Cohort 1921 who were measured on the same traits and states on two occasions (similar to 80 years, N = 550; 87 years, N = 229). For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. Of the inflammatory marker candidate genes, TF showed some association with psychological distress. No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality.

AB - Genetic variants that have previously been associated with personality traits and/or psychological distress, or inflammatory marker levels were investigated for their relationship to self-rated personality traits, anxiety, and depression in two elderly Scottish cohorts. Ten genes (29 SNPs) were investigated in the Lothian Birth Cohort 1936 (similar to 70 years, N = 1,091). Four of these genes and seven others (35 SNPs) were tested in the Lothian Birth Cohort 1921 who were measured on the same traits and states on two occasions (similar to 80 years, N = 550; 87 years, N = 229). For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. Of the inflammatory marker candidate genes, TF showed some association with psychological distress. No SNPs withstood the correction to significance level for multiple testing. Nevertheless, the results will be of importance to future meta-analyses of these candidate genes in relation to psychological distress and personality.

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Association of existing and new candidate genes for anxiety, depression and personality traits in older people

Abstract

Keywords

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