Association between residual inhibition and neural activity in patients with tinnitus: Protocol for a controlled within- And between-subject comparison study

Suyi Hu, Lukas Anschuetz, Markus E. Huth, Raphael Sznitman, Daniela Blaser, Martin Kompis, Deborah A. Hall, Marco Caversaccio, Wilhelm Wimmer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background: Electroencephalography (EEG) studies indicate possible associations between tinnitus and changes in the neural activity. However, inconsistent results require further investigation to better understand such heterogeneity and inform the interpretation of previous findings.

Objective: This study aims to investigate the feasibility of EEG measurements as an objective indicator for the identification of tinnitus-associated neural activities.

Methods: To reduce heterogeneity, participants served as their own control using residual inhibition (RI) to modulate the tinnitus perception in a within-subject EEG study design with a tinnitus group. In addition, comparison with a nontinnitus control group allowed for a between-subjects comparison. We will apply RI stimulation to generate tinnitus and nontinnitus conditions in the same subject. Furthermore, high-frequency audiometry (up to 13 kHz) and tinnitometry will be performed.

Results: This work was funded by the Infrastructure Grant of the University of Bern, Bern, Switzerland and Bernafon AG, Bern, Switzerland. Enrollment for the study described in this protocol commenced in February 2018. Data analysis is currently under way and the first results are expected to be submitted for publication in 2019.Conclusions:This study design helps in comparing the neural activity between conditions in the same individual, thereby addressing a notable limitation of previous EEG tinnitus studies. In addition, the high-frequency assessment will help to analyze and classify tinnitus symptoms beyond the conventional clinical standard.
Original languageEnglish
Article numbere12270
JournalJMIR Research Protocols
Volume8
Issue number1
DOIs
Publication statusPublished - 9 Jan 2019

Keywords

  • Electroencephalography
  • Heterogeneity
  • High-frequency audiometry
  • Neural activity
  • Tinnitometry
  • Tinnitus

ASJC Scopus subject areas

  • General Medicine

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