Association between regional white and gray matter volume and ambiguity tolerance: Evidence from voxel-based morphometry

Dandan Tong; Wenjing Yang; Qinglin Zhang; Wenfu Li; Dongtao Wei; Xianwei Che; Meng Zhang; Glenn Hitchman; Jiang Qiu; Yijun Liu; Guikang Cao

doi:10.1111/psyp.12433

Association between regional white and gray matter volume and ambiguity tolerance: Evidence from voxel-based morphometry

Dandan Tong, Wenjing Yang, Qinglin Zhang, Wenfu Li, Dongtao Wei, Xianwei Che, Meng Zhang, Glenn Hitchman, Jiang Qiu, Yijun Liu, Guikang Cao^*

^*Corresponding author for this work

School of Social Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The concept of tolerance of ambiguity (AT) is defined as the way in which an individual tends to perceive and deal with confusing, vague, and unclear situations. AT is generally considered as an important personality trait, but the neural mechanisms underlying individual differences in AT have never been investigated. Using voxel-based morphometry and MSTAT-II scale, we investigated the correlations between AT and regional white matter volume (rWMV) and regional gray matter volume (rGMV) in 351 young healthy subjects. We found AT to be positively correlated with rGMV in the dorsolateral prefrontal cortex (DLPFC), and negatively correlated with rGMV in the precuneus. These results indicate that increased rGMV in the left DLPFC may lead to characteristics of ambiguous stimuli consideration from multiple contexts and risk taking. Decreased rGMV in the left precuneus may be associated with a high tolerance for ambiguity, which attributes uncertainty to self-related factors.

Original language	English
Pages (from-to)	983-989
Number of pages	7
Journal	Psychophysiology
Volume	52
Issue number	8
DOIs	https://doi.org/10.1111/psyp.12433
Publication status	Published - Aug 2015

Keywords

DLPFC
Precuneus
Tolerance of ambiguity
Voxel-based morphometry

ASJC Scopus subject areas

General Neuroscience
Neuropsychology and Physiological Psychology
Experimental and Cognitive Psychology
Neurology
Endocrine and Autonomic Systems
Developmental Neuroscience
Cognitive Neuroscience
Biological Psychiatry

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10.1111/psyp.12433

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title = "Association between regional white and gray matter volume and ambiguity tolerance: Evidence from voxel-based morphometry",

abstract = "The concept of tolerance of ambiguity (AT) is defined as the way in which an individual tends to perceive and deal with confusing, vague, and unclear situations. AT is generally considered as an important personality trait, but the neural mechanisms underlying individual differences in AT have never been investigated. Using voxel-based morphometry and MSTAT-II scale, we investigated the correlations between AT and regional white matter volume (rWMV) and regional gray matter volume (rGMV) in 351 young healthy subjects. We found AT to be positively correlated with rGMV in the dorsolateral prefrontal cortex (DLPFC), and negatively correlated with rGMV in the precuneus. These results indicate that increased rGMV in the left DLPFC may lead to characteristics of ambiguous stimuli consideration from multiple contexts and risk taking. Decreased rGMV in the left precuneus may be associated with a high tolerance for ambiguity, which attributes uncertainty to self-related factors.",

keywords = "DLPFC, Precuneus, Tolerance of ambiguity, Voxel-based morphometry",

author = "Dandan Tong and Wenjing Yang and Qinglin Zhang and Wenfu Li and Dongtao Wei and Xianwei Che and Meng Zhang and Glenn Hitchman and Jiang Qiu and Yijun Liu and Guikang Cao",

note = "Publisher Copyright: {\textcopyright} 2015 Society for Psychophysiological Research.",

year = "2015",

month = aug,

doi = "10.1111/psyp.12433",

language = "English",

volume = "52",

pages = "983--989",

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T2 - Evidence from voxel-based morphometry

AU - Tong, Dandan

AU - Yang, Wenjing

AU - Zhang, Qinglin

AU - Li, Wenfu

AU - Wei, Dongtao

AU - Che, Xianwei

AU - Zhang, Meng

AU - Hitchman, Glenn

AU - Qiu, Jiang

AU - Liu, Yijun

AU - Cao, Guikang

PY - 2015/8

Y1 - 2015/8

N2 - The concept of tolerance of ambiguity (AT) is defined as the way in which an individual tends to perceive and deal with confusing, vague, and unclear situations. AT is generally considered as an important personality trait, but the neural mechanisms underlying individual differences in AT have never been investigated. Using voxel-based morphometry and MSTAT-II scale, we investigated the correlations between AT and regional white matter volume (rWMV) and regional gray matter volume (rGMV) in 351 young healthy subjects. We found AT to be positively correlated with rGMV in the dorsolateral prefrontal cortex (DLPFC), and negatively correlated with rGMV in the precuneus. These results indicate that increased rGMV in the left DLPFC may lead to characteristics of ambiguous stimuli consideration from multiple contexts and risk taking. Decreased rGMV in the left precuneus may be associated with a high tolerance for ambiguity, which attributes uncertainty to self-related factors.

AB - The concept of tolerance of ambiguity (AT) is defined as the way in which an individual tends to perceive and deal with confusing, vague, and unclear situations. AT is generally considered as an important personality trait, but the neural mechanisms underlying individual differences in AT have never been investigated. Using voxel-based morphometry and MSTAT-II scale, we investigated the correlations between AT and regional white matter volume (rWMV) and regional gray matter volume (rGMV) in 351 young healthy subjects. We found AT to be positively correlated with rGMV in the dorsolateral prefrontal cortex (DLPFC), and negatively correlated with rGMV in the precuneus. These results indicate that increased rGMV in the left DLPFC may lead to characteristics of ambiguous stimuli consideration from multiple contexts and risk taking. Decreased rGMV in the left precuneus may be associated with a high tolerance for ambiguity, which attributes uncertainty to self-related factors.

KW - DLPFC

KW - Precuneus

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Association between regional white and gray matter volume and ambiguity tolerance: Evidence from voxel-based morphometry

Abstract

Keywords

ASJC Scopus subject areas

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