Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments

Birgit K. Gaiser, Teresa F. Fernandes, Mark Jepson, Jamie R. Lead, Charles R. Tyler, Vicki Stone

    Research output: Contribution to journalArticle

    Abstract

    The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and CeO2 particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano CeO2 = micro CeO2. Such consistency suggests that further studies might allow extrapolation of results between different models and species.

    Original languageEnglish
    Article numberS2
    Pages (from-to)-
    Number of pages4
    JournalEnvironmental Health
    Volume8 (supp 1)
    Issue numberS2
    DOIs
    Publication statusPublished - 2009

    Cite this

    Gaiser, Birgit K. ; Fernandes, Teresa F. ; Jepson, Mark ; Lead, Jamie R. ; Tyler, Charles R. ; Stone, Vicki. / Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments. In: Environmental Health. 2009 ; Vol. 8 (supp 1), No. S2. pp. -.
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    Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments. / Gaiser, Birgit K.; Fernandes, Teresa F.; Jepson, Mark; Lead, Jamie R.; Tyler, Charles R.; Stone, Vicki.

    In: Environmental Health, Vol. 8 (supp 1), No. S2, S2, 2009, p. -.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments

    AU - Gaiser, Birgit K.

    AU - Fernandes, Teresa F.

    AU - Jepson, Mark

    AU - Lead, Jamie R.

    AU - Tyler, Charles R.

    AU - Stone, Vicki

    PY - 2009

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    AB - The aim of this project was to compare cerium oxide and silver particles of different sizes for their potential for uptake by aquatic species, human exposure via ingestion of contaminated food sources and to assess their resultant toxicity. The results demonstrate the potential for uptake of nano and larger particles by fish via the gastrointestinal tract, and by human intestinal epithelial cells, therefore suggesting that ingestion is a viable route of uptake into different organism types. A consistency was also shown in the sensitivity of aquatic, fish cell and human cell models to Ag and CeO2 particles of different sizes; with the observed sensitivity sequence from highest to lowest as: nano-Ag > micro Ag > nano CeO2 = micro CeO2. Such consistency suggests that further studies might allow extrapolation of results between different models and species.

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